Motif ID: Hdx

Z-value: 6.316


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.144.0e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3017408 305.046 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 257.523 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3023547 254.191 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3005125 224.645 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3000922 219.858 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3034599 215.520 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3027439 214.309 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3025417 186.771 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr14_-_19418930 173.676 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 151.940 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 139.438 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3036877 138.657 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3037111 129.506 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3013140 120.753 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr2_-_98667264 91.588 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr6_-_23248264 20.461 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr6_+_30568367 9.508 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr3_-_154330543 9.296 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chrX_+_56779699 9.227 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
 Fhl1


four and a half LIM domains 1


chr13_+_24327415 8.732 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1829.6 GO:0008150 biological_process(GO:0008150)
3.4 20.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 17.0 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.3 9.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
3.1 9.4 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 9.3 GO:0021884 forebrain neuron development(GO:0021884)
2.9 8.7 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
1.5 7.7 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.2 6.6 GO:0006270 DNA replication initiation(GO:0006270)
1.2 6.2 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.5 6.0 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.3 5.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 4.1 GO:0043486 histone exchange(GO:0043486)
0.3 3.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.5 3.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 2.1 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.3 2.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.5 1.9 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 1.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.6 1.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1889.7 GO:0005575 cellular_component(GO:0005575)
0.3 9.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.6 9.4 GO:0042101 T cell receptor complex(GO:0042101)
1.5 9.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.5 7.7 GO:0035686 sperm fibrous sheath(GO:0035686)
1.0 5.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 3.7 GO:0071564 npBAF complex(GO:0071564)
0.1 2.1 GO:0031105 septin complex(GO:0031105)
0.2 2.0 GO:0001739 sex chromatin(GO:0001739)
0.4 1.7 GO:0032021 NELF complex(GO:0032021)
0.2 1.7 GO:0005638 lamin filament(GO:0005638)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1865.3 GO:0003674 molecular_function(GO:0003674)
0.1 21.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 9.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.3 9.4 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
2.9 8.7 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
1.9 7.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.4 6.2 GO:0003680 AT DNA binding(GO:0003680)
2.0 6.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.8 5.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 5.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 5.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.7 GO:0031491 nucleosome binding(GO:0031491)
0.2 3.2 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.3 2.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 2.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.3 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 7.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.4 6.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 6.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.2 1.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling