Motif ID: Hes1

Z-value: 1.529


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.612.6e-05Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 31.184 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 28.431 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr11_-_89302545 13.208 ENSMUST00000061728.3
 Nog
noggin
chr14_-_79301623 12.354 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr17_-_25797032 11.333 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr4_+_154960915 10.180 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr1_+_153652943 7.389 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr4_+_65124174 7.356 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr19_+_60144682 6.861 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr4_-_58553553 6.610 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chrX_-_52165252 6.299 ENSMUST00000033450.2
 Gpc4
glypican 4
chr4_-_58553311 5.525 ENSMUST00000107571.1
ENSMUST00000055018.4
 Lpar1

lysophosphatidic acid receptor 1

chr1_-_175692624 5.402 ENSMUST00000027809.7
 Opn3
opsin 3
chr6_-_90716489 5.312 ENSMUST00000101153.3
 Iqsec1
IQ motif and Sec7 domain 1
chr10_-_30842765 5.267 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr5_+_93093428 5.063 ENSMUST00000074733.7
 Sept11
septin 11
chr12_+_110279228 5.022 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr4_-_41695442 4.817 ENSMUST00000102961.3
ENSMUST00000064443.6
 Cntfr

ciliary neurotrophic factor receptor

chr4_-_41695935 4.814 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chr1_-_166309585 4.452 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 59.6 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
3.9 15.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
3.3 13.2 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
3.1 12.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
2.5 10.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
2.4 9.6 GO:0003360 brainstem development(GO:0003360)
0.1 8.1 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.5 7.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.3 6.3 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.8 5.4 GO:0018298 protein-chromophore linkage(GO:0018298)
1.8 5.3 GO:0003195 tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.2 5.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.9 5.2 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 5.1 GO:0051384 response to glucocorticoid(GO:0051384)
0.7 5.0 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.1 4.8 GO:0006879 cellular iron ion homeostasis(GO:0006879)
1.1 4.4 GO:0006545 glycine biosynthetic process(GO:0006545)
0.4 4.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 4.3 GO:0009409 response to cold(GO:0009409)
0.5 4.2 GO:0001842 neural fold formation(GO:0001842)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.5 GO:0005615 extracellular space(GO:0005615)
0.1 16.9 GO:0030139 endocytic vesicle(GO:0030139)
0.0 16.1 GO:0005813 centrosome(GO:0005813)
3.2 9.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 7.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 7.0 GO:0031225 anchored component of membrane(GO:0031225)
0.5 6.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3 5.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 5.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.5 4.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 4.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 4.2 GO:0022626 cytosolic ribosome(GO:0022626)
0.3 4.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.6 3.8 GO:0000235 astral microtubule(GO:0000235)
0.0 3.7 GO:0030018 Z disc(GO:0030018)
0.2 3.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 3.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 3.5 GO:0005719 nuclear euchromatin(GO:0005719)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 59.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
2.2 15.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 13.9 GO:0019955 cytokine binding(GO:0019955)
0.1 12.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 11.0 GO:0070412 R-SMAD binding(GO:0070412)
1.6 9.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 7.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 7.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 6.9 GO:0042393 histone binding(GO:0042393)
0.1 6.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.3 6.3 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 6.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
1.8 5.4 GO:0009881 photoreceptor activity(GO:0009881)
1.8 5.3 GO:0035939 microsatellite binding(GO:0035939)
0.2 5.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.7 GO:0019003 GDP binding(GO:0019003)
1.5 4.4 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.7 4.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 4.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 4.1 GO:0004519 endonuclease activity(GO:0004519)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 63.1 PID_IGF1_PATHWAY IGF1 pathway
0.2 14.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 11.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 11.2 PID_BMP_PATHWAY BMP receptor signaling
0.4 10.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 7.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 6.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 5.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 5.4 PID_CDC42_PATHWAY CDC42 signaling events
0.0 4.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 59.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 27.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 16.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 13.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.5 8.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 7.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 5.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 5.2 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 5.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.5 5.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 4.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 4.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 4.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 4.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 3.4 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 3.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 3.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.0 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 2.9 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events