Motif ID: Hey1_Myc_Mxi1

Z-value: 0.784

Transcription factors associated with Hey1_Myc_Mxi1:

Gene SymbolEntrez IDGene Name
Hey1 ENSMUSG00000040289.3 Hey1
Mxi1 ENSMUSG00000025025.7 Mxi1
Myc ENSMUSG00000022346.8 Myc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mxi1mm10_v2_chr19_+_53329413_53329478-0.343.2e-02Click!
Hey1mm10_v2_chr3_-_8667033_86670460.211.8e-01Click!
Mycmm10_v2_chr15_+_61987034_61987059-0.163.1e-01Click!


Activity profile for motif Hey1_Myc_Mxi1.

activity profile for motif Hey1_Myc_Mxi1


Sorted Z-values histogram for motif Hey1_Myc_Mxi1

Sorted Z-values for motif Hey1_Myc_Mxi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey1_Myc_Mxi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_137314175 4.171 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr10_+_127063599 3.444 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr10_+_127063527 3.442 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr3_+_104638658 3.357 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr2_+_121449362 3.320 ENSMUST00000110615.1
ENSMUST00000099475.5
 Serf2

small EDRK-rich factor 2

chr4_+_101419696 3.132 ENSMUST00000131397.1
ENSMUST00000133055.1
 Ak4

adenylate kinase 4

chr14_-_20181773 2.981 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr8_+_13159135 2.909 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr9_-_114781986 2.889 ENSMUST00000035009.8
ENSMUST00000084867.7
 Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr6_+_88724828 2.859 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr1_-_17097839 2.813 ENSMUST00000038382.4
 Jph1
junctophilin 1
chr2_+_156840966 2.783 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr10_-_30842765 2.772 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr6_+_108660616 2.764 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr6_+_88724462 2.607 ENSMUST00000113582.1
 Mgll
monoglyceride lipase
chr17_+_46496753 2.519 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr5_-_135251209 2.407 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr9_+_107587711 2.396 ENSMUST00000010192.5
 Ifrd2
interferon-related developmental regulator 2
chr6_+_88724412 2.316 ENSMUST00000113585.2
 Mgll
monoglyceride lipase
chr11_+_117809687 2.312 ENSMUST00000120928.1
ENSMUST00000175737.1
 Syngr2

synaptogyrin 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 479 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.7 6.9 GO:0010288 response to lead ion(GO:0010288)
0.4 4.8 GO:0006228 UTP biosynthetic process(GO:0006228)
0.8 4.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.8 4.0 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.9 3.5 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.0 3.5 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.3 3.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.6 3.2 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.4 3.2 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.5 3.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.6 3.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 3.0 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 3.0 GO:0016925 protein sumoylation(GO:0016925)
1.0 2.9 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.7 2.9 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.3 2.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.9 2.8 GO:0003195 tricuspid valve formation(GO:0003195)
0.7 2.7 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.2 2.7 GO:0018195 peptidyl-arginine modification(GO:0018195)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.8 GO:0070062 extracellular exosome(GO:0070062)
0.0 8.3 GO:0005925 focal adhesion(GO:0005925)
0.2 8.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 7.2 GO:0043196 varicosity(GO:0043196)
1.7 6.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 4.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 4.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 4.2 GO:0005642 annulate lamellae(GO:0005642)
0.1 4.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 4.0 GO:0005604 basement membrane(GO:0005604)
0.0 3.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.5 GO:0005921 gap junction(GO:0005921)
0.4 3.4 GO:0031415 NatA complex(GO:0031415)
0.1 3.2 GO:0015934 large ribosomal subunit(GO:0015934)
1.0 3.1 GO:0044194 cytolytic granule(GO:0044194)
0.1 3.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 3.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.6 2.8 GO:0030314 junctional membrane complex(GO:0030314)
0.1 2.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 301 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 9.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 6.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 5.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
1.7 5.2 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 5.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.8 5.1 GO:0043426 MRF binding(GO:0043426)
0.1 5.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 4.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.8 4.0 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 3.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 3.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 3.6 GO:0051920 peroxiredoxin activity(GO:0051920)
0.5 3.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 3.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 3.1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.3 3.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.9 2.8 GO:0035939 microsatellite binding(GO:0035939)
0.1 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 8.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 8.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 5.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 5.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 4.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 4.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.1 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.2 PID_ATM_PATHWAY ATM pathway
0.1 2.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.4 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.5 10.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 7.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 6.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 5.0 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 4.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 4.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 4.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 3.9 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 3.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 3.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.4 3.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 3.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 3.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 2.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 2.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.2 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway