Motif ID: Hey2

Z-value: 0.652


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_30842801-0.362.0e-02Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105518736 6.932 ENSMUST00000034363.5
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr8_+_87473116 5.547 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
Gm2694


predicted gene 2694


chr8_+_87472805 3.707 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
Gm2694


predicted gene 2694


chr8_+_87472838 3.582 ENSMUST00000180806.2
Gm2694
predicted gene 2694
chr4_+_116877376 3.486 ENSMUST00000044823.3
Zswim5
zinc finger SWIM-type containing 5
chr1_-_127677923 3.449 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr6_+_47244359 3.101 ENSMUST00000060839.6
Cntnap2
contactin associated protein-like 2
chr4_-_107683576 2.947 ENSMUST00000131776.1
Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr11_-_120348513 2.783 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr4_-_117133953 2.556 ENSMUST00000076859.5
Plk3
polo-like kinase 3
chr1_+_72824482 2.386 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr11_-_120348475 2.113 ENSMUST00000062147.7
ENSMUST00000128055.1
Actg1

actin, gamma, cytoplasmic 1

chr2_-_114013619 1.980 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr10_-_11080956 1.756 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr1_+_182763961 1.740 ENSMUST00000153348.1
Susd4
sushi domain containing 4
chr7_+_27486910 1.673 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr9_+_21165714 1.646 ENSMUST00000039413.8
Pde4a
phosphodiesterase 4A, cAMP specific
chr8_+_119446719 1.415 ENSMUST00000098363.3
Necab2
N-terminal EF-hand calcium binding protein 2
chr16_-_18621366 1.411 ENSMUST00000051160.2
Gp1bb
glycoprotein Ib, beta polypeptide
chr10_+_69212634 1.228 ENSMUST00000020101.5
Rhobtb1
Rho-related BTB domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.9 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.1 5.7 GO:0045214 sarcomere organization(GO:0045214)
0.6 3.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.3 2.6 GO:0090166 Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
0.1 2.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 2.1 GO:0007601 visual perception(GO:0007601)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 1.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 1.7 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.1 1.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.7 1.4 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167)
0.0 1.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.1 GO:0060325 face morphogenesis(GO:0060325)
0.2 1.0 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 1.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 0.9 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 0.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0043034 costamere(GO:0043034)
0.1 3.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 3.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.6 GO:0005795 Golgi stack(GO:0005795)
0.1 2.0 GO:0005922 connexon complex(GO:0005922)
0.1 1.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.8 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.2 1.6 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 1.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.3 1.0 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.8 GO:0005902 microvillus(GO:0005902)
0.0 0.7 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.7 GO:0014704 intercalated disc(GO:0014704)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.9 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 6.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.0 3.1 GO:0002020 protease binding(GO:0002020)
0.3 2.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 2.3 GO:0002039 p53 binding(GO:0002039)
0.1 1.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.4 1.8 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 1.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.7 1.4 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.1 1.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.9 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 0.8 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 3.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.7 PID_P73PATHWAY p73 transcription factor network
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.4 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 2.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.2 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.7 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 0.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC