Motif ID: Hic1

Z-value: 1.597


Transcription factors associated with Hic1:

Gene SymbolEntrez IDGene Name
Hic1 ENSMUSG00000043099.4 Hic1



Activity profile for motif Hic1.

activity profile for motif Hic1


Sorted Z-values histogram for motif Hic1

Sorted Z-values for motif Hic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 13.385 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr8_-_84800344 9.546 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr2_-_157079212 9.164 ENSMUST00000069098.6
 Soga1
suppressor of glucose, autophagy associated 1
chr6_-_32588192 7.307 ENSMUST00000115096.2
 Plxna4
plexin A4
chr13_+_109903089 7.223 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr7_+_96210107 7.155 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr9_+_45430293 6.885 ENSMUST00000034592.8
 Dscaml1
Down syndrome cell adhesion molecule like 1
chr3_-_148989316 6.713 ENSMUST00000098518.2
 Lphn2
latrophilin 2
chr5_+_141241490 6.652 ENSMUST00000085774.4
 Sdk1
sidekick homolog 1 (chicken)
chr5_+_144768536 6.508 ENSMUST00000128550.1
 Trrap
transformation/transcription domain-associated protein
chr17_-_32788284 6.469 ENSMUST00000159086.2
 Zfp871
zinc finger protein 871
chr5_-_122050102 6.192 ENSMUST00000154139.1
 Cux2
cut-like homeobox 2
chr14_-_30353468 6.024 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr17_-_32284715 5.971 ENSMUST00000127893.1
 Brd4
bromodomain containing 4
chr11_-_6065538 5.788 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr4_-_45084538 5.735 ENSMUST00000052236.6
 Fbxo10
F-box protein 10
chr4_-_123664725 5.518 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr12_+_70825492 5.487 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr7_-_118243564 5.267 ENSMUST00000179047.1
ENSMUST00000032891.8
 Smg1

SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)

chr4_-_46991842 5.125 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 483 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 32.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.3 24.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.2 11.0 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.3 9.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
2.9 8.7 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
2.1 8.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.9 8.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
1.0 8.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.6 8.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 8.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.3 7.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.8 7.3 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
1.8 7.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 6.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 6.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 6.6 GO:1905037 autophagosome organization(GO:1905037)
0.9 6.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.8 6.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 6.2 GO:0030010 establishment of cell polarity(GO:0030010)
0.7 6.0 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 45.4 GO:0016021 integral component of membrane(GO:0016021)
0.1 41.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 25.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 22.2 GO:0000139 Golgi membrane(GO:0000139)
0.4 16.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 12.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 11.1 GO:0051233 spindle midzone(GO:0051233)
0.3 10.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 10.4 GO:0034702 ion channel complex(GO:0034702)
0.2 10.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 10.0 GO:0016605 PML body(GO:0016605)
0.9 9.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
2.9 8.8 GO:0098855 HCN channel complex(GO:0098855)
0.1 8.7 GO:0001726 ruffle(GO:0001726)
0.1 8.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 7.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.6 6.7 GO:0000812 Swr1 complex(GO:0000812)
0.3 6.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 6.0 GO:0031901 early endosome membrane(GO:0031901)
1.0 5.9 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 312 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 14.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5 12.0 GO:0043274 phospholipase binding(GO:0043274)
0.5 10.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
1.3 10.6 GO:0046790 virion binding(GO:0046790)
0.1 10.4 GO:0000287 magnesium ion binding(GO:0000287)
0.6 10.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.1 9.0 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
2.2 8.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 8.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 7.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.6 7.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 7.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.2 7.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.4 6.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 6.9 GO:0008017 microtubule binding(GO:0008017)
0.6 6.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.6 6.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
1.6 6.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 6.3 GO:0035035 histone acetyltransferase binding(GO:0035035)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 12.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 11.9 PID_LKB1_PATHWAY LKB1 signaling events
0.3 11.1 PID_ARF6_PATHWAY Arf6 signaling events
0.2 10.7 PID_SHP2_PATHWAY SHP2 signaling
0.5 10.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 10.0 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.5 8.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 7.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 7.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.2 6.3 PID_MYC_PATHWAY C-MYC pathway
0.2 6.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 5.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 4.9 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.2 4.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 4.3 PID_EPO_PATHWAY EPO signaling pathway
0.2 4.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 4.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 19.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 14.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.3 12.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 12.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 12.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 11.2 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 9.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 8.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 8.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 8.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 6.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.5 6.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 6.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 6.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 5.8 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.2 5.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 5.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 5.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 5.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.4 5.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)