Motif ID: Hic2

Z-value: 1.757


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.105.5e-01Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 9.654 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr15_-_66831625 5.591 ENSMUST00000164163.1
 Sla
src-like adaptor
chr15_+_99224976 5.487 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr7_-_74554474 5.045 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr4_+_154960915 4.726 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr13_-_54055650 4.567 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr11_+_78324200 4.564 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr11_+_104231573 4.252 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr2_-_71546745 4.198 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr11_+_104231465 4.183 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr2_+_70563435 4.050 ENSMUST00000123330.1
 Gad1
glutamate decarboxylase 1
chr2_-_181156993 4.014 ENSMUST00000055990.7
 Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr10_-_109010955 3.993 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr11_+_104231515 3.991 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr4_-_64046925 3.907 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_75193783 3.886 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr11_+_104231390 3.868 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr2_-_163918683 3.859 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr12_+_109549157 3.832 ENSMUST00000128458.1
ENSMUST00000150851.1
 Meg3

maternally expressed 3

chr2_+_180499893 3.757 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 361 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 16.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.3 8.8 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.6 8.3 GO:0015732 prostaglandin transport(GO:0015732)
0.3 7.7 GO:0008340 determination of adult lifespan(GO:0008340)
1.0 7.3 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 6.7 GO:0001553 luteinization(GO:0001553)
1.5 6.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.9 5.8 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.9 5.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 5.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.1 5.4 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.2 4.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.5 4.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 4.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 4.4 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
1.4 4.2 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 4.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.7 4.0 GO:0032796 uropod organization(GO:0032796)
1.0 3.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.3 3.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 16.3 GO:0045298 tubulin complex(GO:0045298)
0.3 14.5 GO:0048786 presynaptic active zone(GO:0048786)
0.6 9.2 GO:0043196 varicosity(GO:0043196)
0.4 8.6 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.5 7.4 GO:0005614 interstitial matrix(GO:0005614)
0.2 7.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 7.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 6.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 5.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 5.5 GO:0071437 invadopodium(GO:0071437)
0.1 4.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 4.2 GO:0044309 neuron spine(GO:0044309)
0.4 4.1 GO:0032426 stereocilium tip(GO:0032426)
0.7 4.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.9 3.8 GO:0032280 symmetric synapse(GO:0032280)
0.2 3.7 GO:0031045 dense core granule(GO:0031045)
1.2 3.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 3.3 GO:0016363 nuclear matrix(GO:0016363)
0.1 3.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.0 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 242 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 16.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.7 8.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.2 8.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.0 7.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 6.6 GO:0022839 ion gated channel activity(GO:0022839)
0.2 5.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 5.8 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.9 5.6 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.6 5.4 GO:0019956 chemokine binding(GO:0019956)
0.2 5.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.3 5.0 GO:0045499 chemorepellent activity(GO:0045499)
0.2 4.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.8 4.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 4.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 4.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 4.3 GO:0003924 GTPase activity(GO:0003924)
0.0 4.1 GO:0017124 SH3 domain binding(GO:0017124)
1.0 4.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.4 4.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.7 3.9 GO:0045545 syndecan binding(GO:0045545)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 16.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 6.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 5.2 PID_CDC42_PATHWAY CDC42 signaling events
0.1 5.1 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 4.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 3.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.9 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.8 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 11.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 7.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 7.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.9 7.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.5 6.3 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 5.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 5.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 4.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.4 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 4.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 4.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 3.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.3 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.1 3.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 2.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac