Motif ID: Hinfp

Z-value: 1.764


Transcription factors associated with Hinfp:

Gene SymbolEntrez IDGene Name
Hinfp ENSMUSG00000032119.4 Hinfp

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hinfpmm10_v2_chr9_-_44305595_44305688-0.444.2e-03Click!


Activity profile for motif Hinfp.

activity profile for motif Hinfp


Sorted Z-values histogram for motif Hinfp

Sorted Z-values for motif Hinfp



Network of associatons between targets according to the STRING database.



First level regulatory network of Hinfp

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_89302545 18.720 ENSMUST00000061728.3
 Nog
noggin
chr19_-_36919606 12.180 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chr3_+_87971129 11.775 ENSMUST00000160694.1
 Nes
nestin
chr3_+_87971071 11.697 ENSMUST00000090973.5
 Nes
nestin
chr13_+_51645232 9.855 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr2_+_84840612 7.666 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr7_+_46845832 7.507 ENSMUST00000048209.9
ENSMUST00000092621.4
 Ldha

lactate dehydrogenase A

chr5_+_108694222 7.204 ENSMUST00000013633.8
ENSMUST00000112560.3
 Fgfrl1

fibroblast growth factor receptor-like 1

chr11_-_8664499 6.950 ENSMUST00000020695.6
 Tns3
tensin 3
chr2_+_70562854 6.854 ENSMUST00000130998.1
 Gad1
glutamate decarboxylase 1
chr4_-_106464167 6.798 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr2_+_163203072 6.130 ENSMUST00000109428.2
 Tox2
TOX high mobility group box family member 2
chr5_+_33658123 6.125 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr12_-_111672290 5.909 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr11_-_106999482 5.824 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr17_-_89910449 5.816 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184
chr7_+_67655414 5.722 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr11_-_106999369 5.601 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr3_-_25212720 5.567 ENSMUST00000091289.3
 Gm10259
predicted pseudogene 10259
chr5_-_8422695 5.492 ENSMUST00000171808.1
 Dbf4
DBF4 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.3 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
4.7 18.7 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
2.2 15.3 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.6 12.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.5 12.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
2.2 10.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.6 10.0 GO:0030953 astral microtubule organization(GO:0030953)
0.4 8.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 7.7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.5 7.5 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.7 7.2 GO:0060539 diaphragm development(GO:0060539)
0.1 7.1 GO:0048286 lung alveolus development(GO:0048286)
2.3 6.9 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
1.7 6.8 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
1.0 5.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 5.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.4 5.7 GO:0006014 D-ribose metabolic process(GO:0006014)
1.4 5.4 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038)
0.3 5.4 GO:0051451 myoblast migration(GO:0051451)
0.5 5.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.8 GO:0005882 intermediate filament(GO:0005882)
1.6 15.6 GO:0000796 condensin complex(GO:0000796)
0.2 14.6 GO:0005643 nuclear pore(GO:0005643)
0.3 9.6 GO:0060077 inhibitory synapse(GO:0060077)
0.1 9.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 9.1 GO:0030424 axon(GO:0030424)
0.1 8.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 8.1 GO:0043209 myelin sheath(GO:0043209)
0.5 7.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 7.2 GO:0005871 kinesin complex(GO:0005871)
0.0 7.2 GO:0005815 microtubule organizing center(GO:0005815)
2.3 6.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 6.5 GO:0044291 cell-cell contact zone(GO:0044291)
1.4 5.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.8 5.4 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.8 5.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 5.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 5.1 GO:0016580 Sin3 complex(GO:0016580)
0.1 5.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 5.0 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 23.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 19.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 16.8 GO:0019955 cytokine binding(GO:0019955)
0.0 14.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.6 13.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
1.7 12.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 10.4 GO:0003735 structural constituent of ribosome(GO:0003735)
2.5 9.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 9.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.3 8.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.9 7.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.8 7.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 7.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 6.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
2.3 6.8 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
1.5 5.9 GO:0004111 creatine kinase activity(GO:0004111)
0.1 5.8 GO:0005080 protein kinase C binding(GO:0005080)
1.9 5.6 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.9 5.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.5 5.4 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 14.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 13.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 12.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 12.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 12.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 10.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 9.1 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 6.6 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 6.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 5.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.5 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 3.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 2.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 18.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.4 15.0 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 14.3 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.5 12.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 10.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 6.3 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.4 6.1 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 5.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 5.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 5.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 5.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 4.9 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1 4.6 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 4.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.2 4.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 3.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.2 3.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation