Motif ID: Hivep1

Z-value: 0.921


Transcription factors associated with Hivep1:

Gene SymbolEntrez IDGene Name
Hivep1 ENSMUSG00000021366.7 Hivep1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hivep1mm10_v2_chr13_+_42052015_420520720.491.3e-03Click!


Activity profile for motif Hivep1.

activity profile for motif Hivep1


Sorted Z-values histogram for motif Hivep1

Sorted Z-values for motif Hivep1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hivep1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 150 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_27616895 8.180 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chr14_+_80000292 6.561 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_-_113758638 5.364 ENSMUST00000099575.3
 Grem1
gremlin 1
chr3_-_88000350 4.571 ENSMUST00000090971.5
 Bcan
brevican
chr7_+_99535652 4.210 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr3_-_107760221 3.919 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr6_-_97487801 3.519 ENSMUST00000113353.1
ENSMUST00000032146.7
 Frmd4b

FERM domain containing 4B

chr7_+_99535439 3.429 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr1_-_156204998 3.408 ENSMUST00000015628.3
 Fam163a
family with sequence similarity 163, member A
chr2_-_104257400 3.164 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr16_+_38089001 3.127 ENSMUST00000023507.6
 Gsk3b
glycogen synthase kinase 3 beta
chr18_+_37496997 3.071 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19
chr4_-_82505749 2.848 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr2_-_5063996 2.641 ENSMUST00000114996.1
 Optn
optineurin
chr18_+_37477768 2.438 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chr2_+_130405256 2.424 ENSMUST00000110281.1
ENSMUST00000028898.3
 1700020A23Rik

RIKEN cDNA 1700020A23 gene

chr3_-_53657339 2.404 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr5_-_134747241 2.247 ENSMUST00000015138.9
 Eln
elastin
chr2_-_5063932 2.237 ENSMUST00000027986.4
 Optn
optineurin
chr5_+_90759299 2.168 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.3 GO:0002158 osteoclast proliferation(GO:0002158)
1.6 8.2 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
1.3 7.6 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 6.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.2 4.9 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 4.8 GO:0007416 synapse assembly(GO:0007416)
0.1 4.6 GO:0021766 hippocampus development(GO:0021766)
0.0 3.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.2 3.2 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
1.0 3.1 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.8 3.0 GO:0009597 detection of virus(GO:0009597)
0.1 2.9 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.7 2.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 2.7 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.5 2.6 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.1 2.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 2.2 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.5 2.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 2.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 1.8 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.6 GO:0031143 pseudopodium(GO:0031143)
0.5 6.6 GO:0042581 specific granule(GO:0042581)
0.2 4.8 GO:0005605 basal lamina(GO:0005605)
0.1 4.2 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 4.2 GO:0030667 secretory granule membrane(GO:0030667)
1.3 3.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.3 3.1 GO:1990909 Wnt signalosome(GO:1990909)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.4 GO:0005604 basement membrane(GO:0005604)
0.7 2.2 GO:0071953 elastic fiber(GO:0071953)
0.2 2.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.6 1.8 GO:0000802 transverse filament(GO:0000802)
0.1 1.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.1 1.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 GO:0045296 cadherin binding(GO:0045296)
2.5 7.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.7 6.6 GO:0036122 BMP binding(GO:0036122)
0.5 4.9 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.3 4.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.9 GO:0005125 cytokine activity(GO:0005125)
0.6 3.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 3.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 3.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.2 GO:0042393 histone binding(GO:0042393)
0.3 2.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 1.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.8 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.4 PID_BMP_PATHWAY BMP receptor signaling
1.0 8.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 7.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 5.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.4 3.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.2 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 2.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 1.8 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 1.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.5 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 1.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.2 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.0 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 0.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 5.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 4.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 3.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.2 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 3.0 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 2.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 1.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.2 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 1.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.0 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.9 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 0.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions