Motif ID: Hlf

Z-value: 0.712


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_90390926-0.462.2e-03Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_88978958 5.820 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr2_+_25180737 2.975 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr4_-_151044564 2.260 ENSMUST00000103204.4
 Per3
period circadian clock 3
chr12_+_117843489 2.257 ENSMUST00000021592.9
 Cdca7l
cell division cycle associated 7 like
chr11_-_77894096 2.207 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr13_+_23531044 2.170 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr19_+_60144682 2.075 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr14_+_50955992 1.928 ENSMUST00000095925.4
 Pnp2
purine-nucleoside phosphorylase 2
chr9_-_107668967 1.812 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr3_+_127553462 1.764 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr14_+_65971049 1.748 ENSMUST00000128539.1
 Clu
clusterin
chr3_+_66219909 1.702 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr4_+_42735545 1.557 ENSMUST00000068158.3
 4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr14_+_65971164 1.526 ENSMUST00000144619.1
 Clu
clusterin
chr7_+_67647405 1.507 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr1_+_156838915 1.490 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr15_-_50889691 1.486 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr14_+_50944499 1.480 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr15_-_98728120 1.462 ENSMUST00000003445.6
 Fkbp11
FK506 binding protein 11
chr17_-_31637135 1.449 ENSMUST00000118504.1
ENSMUST00000078509.5
ENSMUST00000067801.6
 Cbs


cystathionine beta-synthase



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.8 4.5 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.3 3.0 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 2.3 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.7 2.2 GO:0006553 lysine metabolic process(GO:0006553)
0.1 2.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.3 2.0 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.3 2.0 GO:0044838 cell quiescence(GO:0044838)
0.4 1.8 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.3 1.7 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.5 1.5 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.1 1.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.5 1.4 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.5 1.4 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.0 1.4 GO:0042474 middle ear morphogenesis(GO:0042474)
0.2 1.3 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 1.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.3 1.2 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.4 1.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 GO:0005901 caveola(GO:0005901)
0.6 4.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 2.6 GO:0043195 terminal bouton(GO:0043195)
0.0 2.3 GO:0001650 fibrillar center(GO:0001650)
0.3 2.0 GO:0098536 deuterosome(GO:0098536)
0.1 1.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.7 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 1.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.9 GO:0030008 TRAPP complex(GO:0030008)
0.2 0.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.7 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0008565 protein transporter activity(GO:0008565)
0.2 4.5 GO:0051787 misfolded protein binding(GO:0051787)
1.1 3.4 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 2.6 GO:0042393 histone binding(GO:0042393)
0.6 2.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.6 1.8 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.2 1.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 1.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.5 1.4 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.4 GO:0005179 hormone activity(GO:0005179)
0.3 1.3 GO:0004074 biliverdin reductase activity(GO:0004074)
0.3 1.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 1.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 0.9 GO:0070052 collagen V binding(GO:0070052)
0.2 0.9 GO:0032027 myosin light chain binding(GO:0032027)
0.2 0.9 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.5 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 3.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 2.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.1 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 1.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG