Motif ID: Hmbox1

Z-value: 0.993


Transcription factors associated with Hmbox1:

Gene SymbolEntrez IDGene Name
Hmbox1 ENSMUSG00000021972.8 Hmbox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmbox1mm10_v2_chr14_-_64949838_64949886-0.095.7e-01Click!


Activity profile for motif Hmbox1.

activity profile for motif Hmbox1


Sorted Z-values histogram for motif Hmbox1

Sorted Z-values for motif Hmbox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmbox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 129 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 17.122 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr6_+_5390387 11.668 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr2_-_172043466 6.712 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr1_-_75278345 5.207 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chrX_+_100625737 3.695 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr11_-_64436653 3.396 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chrX_+_169685191 3.005 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr13_-_41273977 2.795 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr13_-_3893556 2.687 ENSMUST00000099946.4
 Net1
neuroepithelial cell transforming gene 1
chr8_+_45507768 2.151 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr4_-_97584612 2.144 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr3_-_79842662 1.954 ENSMUST00000029568.1
 Tmem144
transmembrane protein 144
chrX_-_23266751 1.821 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr3_-_100969644 1.798 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chr10_-_49783259 1.789 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr8_+_45658666 1.762 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr13_-_90905321 1.741 ENSMUST00000109541.3
 Atp6ap1l
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr10_+_39133981 1.726 ENSMUST00000019991.7
 Tube1
epsilon-tubulin 1
chrX_+_169879596 1.695 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr8_+_45658731 1.670 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 17.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 11.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 5.9 GO:0009306 protein secretion(GO:0009306)
0.1 5.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 4.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 3.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.7 GO:0051451 myoblast migration(GO:0051451)
0.2 2.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.2 1.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 1.8 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.4 1.7 GO:0099566 dimeric G-protein coupled receptor signaling pathway(GO:0038042) regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.7 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 1.7 GO:0000910 cytokinesis(GO:0000910)
0.1 1.4 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.4 1.3 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.3 1.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 1.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 1.2 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.2 1.1 GO:0007343 egg activation(GO:0007343)
0.0 1.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 11.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
1.0 5.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 4.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 4.6 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.0 GO:0030496 midbody(GO:0030496)
0.1 3.7 GO:0045171 intercellular bridge(GO:0045171)
0.3 1.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.8 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.7 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.4 1.4 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 1.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)
0.1 1.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.8 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.7 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 0.7 GO:0033503 HULC complex(GO:0033503)
0.1 0.7 GO:0045298 tubulin complex(GO:0045298)
0.0 0.7 GO:0090544 BAF-type complex(GO:0090544)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 11.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 3.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 2.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 2.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 1.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 1.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 1.7 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.3 1.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 1.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 1.3 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 1.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.2 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.1 GO:0005254 chloride channel activity(GO:0005254)
0.3 1.0 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 1.0 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 0.7 GO:0004017 adenylate kinase activity(GO:0004017)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus