Motif ID: Hmga1

Z-value: 1.275


Transcription factors associated with Hmga1:

Gene SymbolEntrez IDGene Name
Hmga1 ENSMUSG00000046711.9 Hmga1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga1mm10_v2_chr17_+_27556668_275566900.067.0e-01Click!


Activity profile for motif Hmga1.

activity profile for motif Hmga1


Sorted Z-values histogram for motif Hmga1

Sorted Z-values for motif Hmga1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 27.080 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_102010138 6.032 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr15_-_56694525 5.976 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr17_+_43953191 5.857 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr16_-_26989974 5.511 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr10_-_33624587 4.965 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr10_-_92165159 4.550 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr1_-_158814469 4.443 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr17_+_43952999 4.320 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr1_+_107511416 4.133 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr12_+_52699297 4.016 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr4_-_36056726 3.950 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr10_+_96136603 3.791 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chr12_+_72441933 3.742 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chrX_-_103483205 3.506 ENSMUST00000127786.2
 Xist
inactive X specific transcripts
chr12_-_108003594 3.423 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr8_+_45658666 3.262 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 3.236 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr8_-_87959560 3.195 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr2_+_125866107 3.018 ENSMUST00000134337.1
ENSMUST00000094604.2
ENSMUST00000134798.1
 Galk2


galactokinase 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 20.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 13.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.2 8.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.5 6.0 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 6.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 5.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 5.0 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 4.3 GO:0060349 bone morphogenesis(GO:0060349)
1.0 4.0 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.4 3.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 3.6 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
1.2 3.5 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 3.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.6 3.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 3.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
1.0 3.0 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.3 3.0 GO:0006012 galactose metabolic process(GO:0006012)
0.1 3.0 GO:0006270 DNA replication initiation(GO:0006270)
0.6 2.8 GO:0060467 negative regulation of fertilization(GO:0060467)
0.5 2.8 GO:0072318 clathrin coat disassembly(GO:0072318)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.2 GO:0014069 postsynaptic density(GO:0014069)
0.0 6.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 4.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 4.1 GO:0042641 actomyosin(GO:0042641)
0.2 4.0 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 3.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.4 3.5 GO:0000805 X chromosome(GO:0000805)
0.3 3.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 3.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 3.1 GO:0070469 respiratory chain(GO:0070469)
0.0 2.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.7 GO:0043034 costamere(GO:0043034)
0.1 2.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 2.5 GO:0005801 cis-Golgi network(GO:0005801)
0.5 2.4 GO:0044316 cone cell pedicle(GO:0044316)
0.2 2.4 GO:0070852 cell body fiber(GO:0070852)
0.0 2.3 GO:0001650 fibrillar center(GO:0001650)
0.0 2.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.7 10.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
2.0 6.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 5.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 5.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 4.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 4.0 GO:0043495 protein anchor(GO:0043495)
0.2 3.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 3.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 3.2 GO:0005112 Notch binding(GO:0005112)
1.0 3.0 GO:0004335 galactokinase activity(GO:0004335)
0.2 2.8 GO:0045499 chemorepellent activity(GO:0045499)
0.9 2.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 2.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.2 2.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 6.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.0 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 2.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.8 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.9 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.3 4.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 2.5 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 2.4 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 2.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.4 2.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.2 2.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.1 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 2.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling