Motif ID: Hmx1

Z-value: 0.802


Transcription factors associated with Hmx1:

Gene SymbolEntrez IDGene Name
Hmx1 ENSMUSG00000067438.3 Hmx1



Activity profile for motif Hmx1.

activity profile for motif Hmx1


Sorted Z-values histogram for motif Hmx1

Sorted Z-values for motif Hmx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_79301623 5.531 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr2_+_164562579 4.697 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr6_+_108660616 4.416 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr10_-_77113676 4.343 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr7_-_116308241 4.282 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr7_-_48881032 4.208 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr5_+_114568016 4.074 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr1_-_165194310 4.008 ENSMUST00000043338.4
 Sft2d2
SFT2 domain containing 2
chr8_+_94152607 3.995 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr17_-_23684019 3.789 ENSMUST00000085989.5
 Cldn9
claudin 9
chr6_+_108660772 3.776 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr6_-_127151044 3.680 ENSMUST00000000188.8
 Ccnd2
cyclin D2
chr8_+_54077532 3.500 ENSMUST00000033919.4
 Vegfc
vascular endothelial growth factor C
chr7_-_144939823 3.444 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr2_+_168081004 3.176 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr6_-_95718800 2.997 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr9_+_108560422 2.975 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr1_+_52008210 2.915 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr17_-_33890539 2.482 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr17_-_33890584 2.402 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.2 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
1.4 5.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.3 5.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.6 4.9 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.0 4.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.7 4.3 GO:0045218 zonula adherens maintenance(GO:0045218)
1.4 4.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.3 4.0 GO:0097212 lysosomal membrane organization(GO:0097212)
0.1 3.8 GO:0048747 muscle fiber development(GO:0048747)
0.3 3.7 GO:0071481 cellular response to X-ray(GO:0071481)
0.9 3.5 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.5 3.4 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 3.1 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.6 3.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 3.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 2.9 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 2.3 GO:0032526 response to retinoic acid(GO:0032526)
0.7 2.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 2.2 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.1 2.2 GO:0010883 regulation of lipid storage(GO:0010883)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.7 GO:0005581 collagen trimer(GO:0005581)
0.1 5.3 GO:0016528 sarcoplasm(GO:0016528)
0.2 5.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 4.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 4.3 GO:0005915 zonula adherens(GO:0005915)
0.1 4.2 GO:0005871 kinesin complex(GO:0005871)
0.9 3.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.5 3.0 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 3.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 2.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 1.9 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.9 GO:0031519 PcG protein complex(GO:0031519)
0.3 1.7 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 1.6 GO:0031523 Myb complex(GO:0031523)
0.3 1.6 GO:0045179 apical cortex(GO:0045179)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 8.2 GO:0043426 MRF binding(GO:0043426)
0.0 6.2 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.0 6.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 5.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 5.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 5.1 GO:0001047 core promoter binding(GO:0001047)
0.3 4.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.9 4.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 4.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 4.2 GO:0003777 microtubule motor activity(GO:0003777)
0.3 3.8 GO:0001618 virus receptor activity(GO:0001618)
0.1 3.4 GO:0070064 proline-rich region binding(GO:0070064)
0.3 3.3 GO:0001972 retinoic acid binding(GO:0001972)
1.0 3.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.7 3.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 2.1 GO:0042056 chemoattractant activity(GO:0042056)
0.2 2.0 GO:0019956 chemokine binding(GO:0019956)
0.0 2.0 GO:0003774 motor activity(GO:0003774)
0.4 1.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 1.9 GO:0070097 delta-catenin binding(GO:0070097)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 6.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 5.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 4.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.3 3.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 2.9 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 2.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.0 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.9 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 7.9 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 6.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 4.9 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 3.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 3.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 2.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 1.8 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.2 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.7 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis