Motif ID: Hmx3

Z-value: 0.322


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.143.7e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 57 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_49757257 1.276 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr4_+_144893127 1.138 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_-_190170671 1.010 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr15_+_9436028 0.884 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr12_-_83487708 0.871 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr3_+_62419668 0.808 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr4_+_154960915 0.723 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr1_+_165788681 0.584 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr9_-_123678873 0.556 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr2_-_72986716 0.541 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr9_-_123678782 0.522 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr14_-_55560340 0.488 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr4_-_62470868 0.387 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr10_+_99263224 0.368 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr6_+_92092369 0.355 ENSMUST00000113463.1
 Nr2c2
nuclear receptor subfamily 2, group C, member 2
chr7_+_25681158 0.350 ENSMUST00000108403.3
 B9d2
B9 protein domain 2
chr7_-_126897424 0.347 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr1_-_119836999 0.342 ENSMUST00000163621.1
ENSMUST00000168303.1
 Ptpn4

protein tyrosine phosphatase, non-receptor type 4

chr2_-_130424673 0.328 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A
chr12_-_83921809 0.320 ENSMUST00000135962.1
ENSMUST00000155112.1
ENSMUST00000136848.1
ENSMUST00000126943.1
 Numb



numb gene homolog (Drosophila)




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.1 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.1 1.1 GO:0042572 retinol metabolic process(GO:0042572)
0.3 1.0 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 0.7 GO:2000977 regulation of forebrain neuron differentiation(GO:2000977)
0.0 0.6 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.4 GO:0030862 neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 0.4 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.4 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.3 GO:0032570 response to progesterone(GO:0032570)
0.1 0.2 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.2 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0071565 nBAF complex(GO:0071565)
0.1 0.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.3 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.0 GO:0002944 cyclin K-CDK12 complex(GO:0002944)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 1.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation