Motif ID: Hnf4a

Z-value: 0.844


Transcription factors associated with Hnf4a:

Gene SymbolEntrez IDGene Name
Hnf4a ENSMUSG00000017950.10 Hnf4a



Activity profile for motif Hnf4a.

activity profile for motif Hnf4a


Sorted Z-values histogram for motif Hnf4a

Sorted Z-values for motif Hnf4a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf4a

PNG image of the network

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Top targets:


Showing 1 to 20 of 192 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_101840602 5.162 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr2_-_131042682 4.458 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr14_+_101840501 4.322 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr2_-_131043088 3.674 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr3_-_84305385 3.619 ENSMUST00000122849.1
ENSMUST00000132283.1
 Trim2

tripartite motif-containing 2

chr1_-_155417394 3.610 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr7_+_25268387 3.462 ENSMUST00000169392.1
 Cic
capicua homolog (Drosophila)
chr1_-_77515048 3.116 ENSMUST00000027451.6
 Epha4
Eph receptor A4
chr4_+_136286061 3.083 ENSMUST00000069195.4
ENSMUST00000130658.1
 Zfp46

zinc finger protein 46

chr11_+_104282371 2.952 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr15_-_102722120 2.945 ENSMUST00000171838.1
 Calcoco1
calcium binding and coiled coil domain 1
chr7_+_112225856 2.842 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr5_+_19907774 2.719 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr8_-_41016295 2.703 ENSMUST00000131965.1
 Mtus1
mitochondrial tumor suppressor 1
chr2_+_3704787 2.676 ENSMUST00000115054.2
 Fam107b
family with sequence similarity 107, member B
chr15_-_102722150 2.618 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1
chrX_-_105929206 2.594 ENSMUST00000134381.1
ENSMUST00000154866.1
 Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr15_+_3270767 2.536 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr6_-_41636389 2.526 ENSMUST00000031902.5
 Trpv6
transient receptor potential cation channel, subfamily V, member 6
chrX_-_105929333 2.513 ENSMUST00000134507.1
ENSMUST00000137453.1
ENSMUST00000150914.1
 Atrx


alpha thalassemia/mental retardation syndrome X-linked homolog (human)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.1 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 7.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.6 6.6 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.8 6.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.9 5.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 5.2 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 4.9 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.6 4.8 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.4 3.9 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
1.0 3.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.6 2.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 2.7 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.4 2.5 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 2.4 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.2 2.4 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.4 2.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.4 2.2 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.6 1.9 GO:0006553 lysine metabolic process(GO:0006553)
0.1 1.9 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.6 1.8 GO:0071929 alpha-tubulin acetylation(GO:0071929)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0005913 cell-cell adherens junction(GO:0005913)
1.6 6.6 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.7 6.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 4.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.1 GO:0044295 axonal growth cone(GO:0044295)
0.3 3.0 GO:0045298 tubulin complex(GO:0045298)
0.1 2.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 2.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.4 2.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 2.0 GO:0031526 brush border membrane(GO:0031526)
0.0 1.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.4 1.8 GO:1990130 Iml1 complex(GO:1990130)
0.2 1.8 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.6 GO:0005882 intermediate filament(GO:0005882)
0.0 1.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 1.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 1.2 GO:0070695 FHF complex(GO:0070695)
0.0 1.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.5 GO:0042805 actinin binding(GO:0042805)
2.7 8.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.9 6.6 GO:0015616 DNA translocase activity(GO:0015616)
0.1 5.9 GO:0017022 myosin binding(GO:0017022)
1.9 5.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 5.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 4.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 4.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 3.2 GO:0071949 FAD binding(GO:0071949)
0.5 3.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731)
0.4 3.0 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 2.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 2.5 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 2.3 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 2.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 1.9 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 5.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.1 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.2 3.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 2.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.1 1.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 6.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 4.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 4.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 3.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.1 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.1 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.2 1.0 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 0.8 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.8 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis