Motif ID: Homez

Z-value: 0.656


Transcription factors associated with Homez:

Gene SymbolEntrez IDGene Name
Homez ENSMUSG00000057156.9 Homez

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Homezmm10_v2_chr14_-_54870913_54870961-0.296.2e-02Click!


Activity profile for motif Homez.

activity profile for motif Homez


Sorted Z-values histogram for motif Homez

Sorted Z-values for motif Homez



Network of associatons between targets according to the STRING database.



First level regulatory network of Homez

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 5.280 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 3.120 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr18_+_50030977 2.138 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr4_-_117178726 2.013 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr4_+_44300876 1.896 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr19_-_36919606 1.730 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chr17_+_87635974 1.716 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr8_-_4779513 1.701 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr11_+_101627942 1.693 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr2_+_71389239 1.416 ENSMUST00000028408.2
 Hat1
histone aminotransferase 1
chr8_+_116921735 1.396 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr5_-_8422695 1.358 ENSMUST00000171808.1
 Dbf4
DBF4 homolog (S. cerevisiae)
chr19_-_12501996 1.342 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr18_+_86711059 1.339 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein
chr7_-_62464505 1.314 ENSMUST00000094339.2
 Peg12
paternally expressed 12
chr3_+_5218546 1.311 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr5_-_8422582 1.305 ENSMUST00000168500.1
ENSMUST00000002368.9
 Dbf4

DBF4 homolog (S. cerevisiae)

chr9_+_91368811 1.299 ENSMUST00000173054.1
 Zic4
zinc finger protein of the cerebellum 4
chr8_-_72305276 1.294 ENSMUST00000075602.6
 Gm10282
predicted pseudogene 10282
chr9_+_91368970 1.279 ENSMUST00000172646.1
 Zic4
zinc finger protein of the cerebellum 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 5.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 3.2 GO:0006270 DNA replication initiation(GO:0006270)
0.5 2.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 2.4 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.4 2.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 1.7 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.4 1.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 1.7 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 1.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.5 1.5 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.2 1.4 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 1.4 GO:0034508 centromere complex assembly(GO:0034508)
0.1 1.3 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 1.3 GO:0000578 embryonic axis specification(GO:0000578)
0.3 1.2 GO:1902608 regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.1 1.2 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 1.2 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 1.2 GO:0032526 response to retinoic acid(GO:0032526)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.5 1.5 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 1.5 GO:0005801 cis-Golgi network(GO:0005801)
0.3 1.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.2 GO:0070652 HAUS complex(GO:0070652)
0.1 1.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.3 0.9 GO:1990423 RZZ complex(GO:1990423)
0.2 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.9 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 0.9 GO:0000243 commitment complex(GO:0000243)
0.1 0.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0005657 replication fork(GO:0005657)
0.1 0.8 GO:0071817 MMXD complex(GO:0071817)
0.1 0.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.1 1.4 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 1.4 GO:0042169 SH2 domain binding(GO:0042169)
0.2 1.2 GO:0042731 PH domain binding(GO:0042731)
0.1 1.1 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 1.0 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.3 1.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.3 1.0 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.2 1.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 1.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 1.0 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.9 GO:0061649 ubiquitinated histone binding(GO:0061649)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 2.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.1 3.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 2.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.5 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.3 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.0 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.9 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis