Motif ID: Hoxa1

Z-value: 1.041


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_143299498 9.989 ENSMUST00000030317.7
 Pdpn
podoplanin
chr2_+_163225363 6.152 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr7_+_73391160 5.213 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr14_+_70077375 4.783 ENSMUST00000035908.1
 Egr3
early growth response 3
chr9_+_15239045 4.515 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr14_-_103844173 3.960 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr4_-_143299463 3.886 ENSMUST00000119654.1
 Pdpn
podoplanin
chr3_+_55782500 3.807 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr19_-_41743665 3.782 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr9_-_96862903 3.532 ENSMUST00000121077.1
ENSMUST00000124923.1
 Acpl2

acid phosphatase-like 2

chr2_+_158375638 2.844 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr2_-_26246707 2.761 ENSMUST00000166349.1
 C030048H21Rik
RIKEN cDNA C030048H21 gene
chr15_-_95528702 2.655 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr13_-_60177357 2.655 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr2_+_152962485 2.645 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr3_-_110143937 2.621 ENSMUST00000051253.3
 Ntng1
netrin G1
chr1_+_153665274 2.584 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr10_+_26078255 2.211 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr15_+_98167806 2.010 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr5_+_27261916 1.984 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 13.9 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.4 5.2 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.4 4.8 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
1.3 4.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.5 3.8 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 3.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 2.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.2 2.7 GO:0042473 outer ear morphogenesis(GO:0042473)
0.2 2.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 2.0 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.2 1.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 1.7 GO:0042711 maternal behavior(GO:0042711)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.4 1.6 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 1.5 GO:0009409 response to cold(GO:0009409)
0.2 1.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2 1.2 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 1.0 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 1.0 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 13.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 5.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.7 GO:0043204 perikaryon(GO:0043204)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.2 1.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.4 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 13.9 GO:0015250 water channel activity(GO:0015250)
0.0 6.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.4 5.2 GO:1990459 transferrin receptor binding(GO:1990459)
1.3 4.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.5 3.8 GO:0048495 Roundabout binding(GO:0048495)
0.0 3.8 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 3.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.7 GO:0005080 protein kinase C binding(GO:0005080)
0.1 2.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 2.1 GO:0016874 ligase activity(GO:0016874)
0.0 2.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 1.6 GO:0031432 thyroid hormone receptor coactivator activity(GO:0030375) titin binding(GO:0031432)
0.1 1.5 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.2 GO:0005125 cytokine activity(GO:0005125)
0.3 1.1 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.2 1.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 PID_BMP_PATHWAY BMP receptor signaling
0.1 4.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 4.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 2.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 1.1 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions