Motif ID: Hoxa10

Z-value: 0.813


Transcription factors associated with Hoxa10:

Gene SymbolEntrez IDGene Name
Hoxa10 ENSMUSG00000000938.11 Hoxa10



Activity profile for motif Hoxa10.

activity profile for motif Hoxa10


Sorted Z-values histogram for motif Hoxa10

Sorted Z-values for motif Hoxa10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa10

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_34354119 5.469 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr8_+_106935720 5.165 ENSMUST00000047425.3
 Sntb2
syntrophin, basic 2
chr17_+_29093763 4.532 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr3_+_102010138 4.110 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr11_+_44617310 3.787 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr2_+_102658640 3.278 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_-_79908428 2.503 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr11_-_78984831 2.499 ENSMUST00000073001.4
ENSMUST00000108269.3
 Lgals9

lectin, galactose binding, soluble 9

chr8_+_58912257 2.377 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr1_+_66321708 2.190 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr10_-_11082287 2.094 ENSMUST00000105561.2
ENSMUST00000044306.6
 Grm1

glutamate receptor, metabotropic 1

chr11_-_78984946 2.046 ENSMUST00000108268.3
 Lgals9
lectin, galactose binding, soluble 9
chrX_+_56609843 1.879 ENSMUST00000077741.5
ENSMUST00000114784.2
 Slc9a6

solute carrier family 9 (sodium/hydrogen exchanger), member 6

chr2_-_79908389 1.752 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr11_-_42000284 1.600 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr11_-_69822144 1.548 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr13_+_24614608 1.404 ENSMUST00000091694.3
 Fam65b
family with sequence similarity 65, member B
chr2_+_68117713 1.402 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_-_43274786 1.372 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr2_-_37647199 1.343 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 5.5 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
1.5 4.5 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.5 4.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.2 4.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 4.1 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.5 3.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 3.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.5 2.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 2.0 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.3 1.9 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.2 1.9 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.2 1.6 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.5 GO:0030317 sperm motility(GO:0030317)
0.2 1.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.3 1.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 1.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 1.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 1.3 GO:0007638 mechanosensory behavior(GO:0007638)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 3.3 GO:0030673 axolemma(GO:0030673)
0.0 2.6 GO:0072562 blood microparticle(GO:0072562)
0.2 2.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.1 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.3 1.9 GO:0044308 axonal spine(GO:0044308)
0.0 1.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0043204 perikaryon(GO:0043204)
0.1 1.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.1 GO:0043196 varicosity(GO:0043196)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.0 GO:0045202 synapse(GO:0045202)
0.3 0.9 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.1 0.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.7 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.2 0.6 GO:0044299 C-fiber(GO:0044299)
0.1 0.6 GO:0008091 spectrin(GO:0008091)
0.1 0.6 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.5 4.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.8 4.5 GO:0016936 galactoside binding(GO:0016936)
0.6 4.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 4.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 3.9 GO:0005516 calmodulin binding(GO:0005516)
0.3 3.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.5 3.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 3.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 2.1 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.5 1.9 GO:0001851 complement component C3b binding(GO:0001851)
0.2 1.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.7 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 1.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.3 1.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 1.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 1.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 1.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 4.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 2.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 0.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.2 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 4.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 3.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 1.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 1.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.0 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.7 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors