Motif ID: Hoxa11_Hoxc12

Z-value: 1.093

Transcription factors associated with Hoxa11_Hoxc12:

Gene SymbolEntrez IDGene Name
Hoxa11 ENSMUSG00000038210.9 Hoxa11
Hoxc12 ENSMUSG00000050328.2 Hoxc12



Activity profile for motif Hoxa11_Hoxc12.

activity profile for motif Hoxa11_Hoxc12


Sorted Z-values histogram for motif Hoxa11_Hoxc12

Sorted Z-values for motif Hoxa11_Hoxc12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa11_Hoxc12

PNG image of the network

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Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_35076902 15.933 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_+_43730593 8.692 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr1_-_56978534 8.560 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr14_+_80000292 7.358 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr17_+_6270475 6.869 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr6_+_108213086 6.554 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr17_-_6477102 5.267 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr16_-_57231434 4.894 ENSMUST00000023431.6
 Tbc1d23
TBC1 domain family, member 23
chr13_+_16014457 4.656 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr18_+_69346143 4.430 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr15_-_43869993 4.382 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr11_-_62457772 3.768 ENSMUST00000127471.2
 Ncor1
nuclear receptor co-repressor 1
chr17_+_22361453 3.499 ENSMUST00000149699.1
ENSMUST00000088765.2
ENSMUST00000072477.4
ENSMUST00000121315.1
 Zfp758



zinc finger protein 758



chr5_+_66968961 3.125 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chrX_+_73064787 3.044 ENSMUST00000060418.6
 Pnma3
paraneoplastic antigen MA3
chrX_+_41401128 2.788 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr18_+_37655891 2.631 ENSMUST00000097608.2
 3222401L13Rik
RIKEN cDNA 3222401L13 gene
chrX_+_41401304 2.576 ENSMUST00000076349.5
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr16_-_45408955 2.561 ENSMUST00000163230.1
 Cd200
CD200 antigen
chr16_-_74411776 2.479 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.9 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
1.1 8.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.5 8.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 7.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.1 6.9 GO:0009405 pathogenesis(GO:0009405)
1.1 6.6 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 5.4 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 5.4 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.9 4.7 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
1.5 4.4 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.4 4.4 GO:0042118 endothelial cell activation(GO:0042118)
0.0 4.4 GO:0016236 macroautophagy(GO:0016236)
0.9 3.8 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.0 3.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.9 2.6 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.8 2.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 2.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 2.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 1.9 GO:0030317 sperm motility(GO:0030317)
0.6 1.7 GO:0072720 response to sorbitol(GO:0072708) response to dithiothreitol(GO:0072720)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.7 GO:0031045 dense core granule(GO:0031045)
0.1 8.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.5 7.4 GO:0042581 specific granule(GO:0042581)
2.2 6.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 6.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.4 5.4 GO:0043083 synaptic cleft(GO:0043083)
1.6 4.7 GO:0043512 inhibin A complex(GO:0043512)
0.2 3.8 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.5 GO:0030673 axolemma(GO:0030673)
0.4 2.2 GO:1990393 3M complex(GO:1990393)
0.0 2.1 GO:0048786 presynaptic active zone(GO:0048786)
0.2 1.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 1.7 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.2 1.6 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 1.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 1.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 15.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 9.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.5 6.9 GO:0015643 toxic substance binding(GO:0015643)
0.0 6.8 GO:0003682 chromatin binding(GO:0003682)
2.2 6.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.8 5.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.8 4.7 GO:0070699 type II activin receptor binding(GO:0070699)
1.1 4.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.7 4.4 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.5 3.8 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.3 2.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 2.3 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.2 GO:0042608 T cell receptor binding(GO:0042608)
0.1 2.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 1.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.4 1.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.7 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 5.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 4.7 PID_ALK1_PATHWAY ALK1 signaling events
0.0 3.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.3 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.2 4.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 4.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 1.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters