Motif ID: Hoxa13

Z-value: 0.688


Transcription factors associated with Hoxa13:

Gene SymbolEntrez IDGene Name
Hoxa13 ENSMUSG00000038203.12 Hoxa13



Activity profile for motif Hoxa13.

activity profile for motif Hoxa13


Sorted Z-values histogram for motif Hoxa13

Sorted Z-values for motif Hoxa13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa13

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893127 2.814 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_-_154636831 2.767 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr3_-_49757257 2.699 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr17_+_75178797 2.581 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chrY_-_1286563 2.427 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr1_-_45503282 2.424 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr17_+_75178911 2.255 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chrX_+_82948861 2.184 ENSMUST00000114000.1
 Dmd
dystrophin, muscular dystrophy
chr6_-_125494754 2.116 ENSMUST00000032492.8
 Cd9
CD9 antigen
chr5_+_117841839 2.080 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr15_+_83791939 2.003 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr2_+_126215100 1.990 ENSMUST00000164042.2
 Gm17555
predicted gene, 17555
chr15_+_3270767 1.957 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr6_+_125215551 1.912 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
 Vamp1


vesicle-associated membrane protein 1


chr16_-_31314804 1.893 ENSMUST00000115230.1
ENSMUST00000130560.1
 Apod

apolipoprotein D

chr3_-_80802789 1.875 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr10_-_116972609 1.857 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr17_-_35074485 1.766 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr1_-_173942445 1.741 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr5_-_62766153 1.733 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 3.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 3.1 GO:0046847 filopodium assembly(GO:0046847)
0.3 2.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 2.8 GO:0042572 retinol metabolic process(GO:0042572)
0.2 2.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 2.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.7 2.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.7 2.1 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.4 2.1 GO:0030913 paranodal junction assembly(GO:0030913)
0.6 1.9 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097) negative regulation of lymphocyte migration(GO:2000402)
0.1 1.9 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 1.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.8 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 1.8 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 1.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 1.6 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.6 GO:1901629 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of presynaptic membrane organization(GO:1901629)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 4.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 3.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.5 GO:0016235 aggresome(GO:0016235)
0.8 2.4 GO:0005588 collagen type V trimer(GO:0005588)
0.8 2.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 2.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 2.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 2.1 GO:0070469 respiratory chain(GO:0070469)
0.4 1.9 GO:0070820 tertiary granule(GO:0070820)
0.1 1.9 GO:0032279 asymmetric synapse(GO:0032279)
0.3 1.7 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 1.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.4 GO:0098644 complex of collagen trimers(GO:0098644)
0.2 1.1 GO:0097513 myosin II filament(GO:0097513)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.0 GO:0030175 filopodium(GO:0030175)
0.1 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.8 GO:0050436 microfibril binding(GO:0050436)
0.0 3.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 2.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 2.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.6 2.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 2.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 2.2 GO:0017166 vinculin binding(GO:0017166)
0.7 2.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 2.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 2.1 GO:0005178 integrin binding(GO:0005178)
0.0 1.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.9 GO:0015485 cholesterol binding(GO:0015485)
0.2 1.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.4 1.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.4 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.6 PID_ATM_PATHWAY ATM pathway
0.0 1.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 1.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.9 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.1 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.9 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.0 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis