Motif ID: Hoxa2

Z-value: 0.998


Transcription factors associated with Hoxa2:

Gene SymbolEntrez IDGene Name
Hoxa2 ENSMUSG00000014704.8 Hoxa2



Activity profile for motif Hoxa2.

activity profile for motif Hoxa2


Sorted Z-values histogram for motif Hoxa2

Sorted Z-values for motif Hoxa2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 12.633 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_117342949 7.563 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr2_-_117342831 7.190 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr12_+_109747903 6.981 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr2_-_117342709 6.974 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr14_-_34374617 6.075 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr8_-_4779513 4.629 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr3_+_55782500 4.341 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr10_-_26078987 3.929 ENSMUST00000066049.6
 Tmem200a
transmembrane protein 200A
chr7_+_45163915 3.888 ENSMUST00000085374.5
 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr11_-_58801944 3.397 ENSMUST00000094156.4
ENSMUST00000060581.3
 Fam183b

family with sequence similarity 183, member B

chr8_-_87959560 3.392 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr9_-_106158109 3.374 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr1_-_133907053 3.241 ENSMUST00000149380.1
ENSMUST00000124051.2
 Optc

opticin

chr9_-_73968901 3.166 ENSMUST00000184666.1
 Unc13c
unc-13 homolog C (C. elegans)
chr17_-_53539411 2.951 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr16_-_23890805 2.929 ENSMUST00000004480.3
 Sst
somatostatin
chrX_-_103483205 2.925 ENSMUST00000127786.2
 Xist
inactive X specific transcripts
chr10_-_92162753 2.880 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr1_-_133906973 2.829 ENSMUST00000126123.1
 Optc
opticin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 21.7 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
1.8 12.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 6.7 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 6.0 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.1 4.6 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.9 4.3 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
1.3 3.9 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.0 3.8 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 3.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.4 3.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.0 3.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.0 2.9 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.6 2.9 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.4 2.8 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.3 2.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 2.6 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.5 2.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.6 2.4 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.4 2.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 2.4 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 4.8 GO:0005635 nuclear envelope(GO:0005635)
0.2 4.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 4.5 GO:0097546 ciliary base(GO:0097546)
0.0 4.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.4 3.9 GO:0000805 X chromosome(GO:0000805)
0.5 3.2 GO:0044305 calyx of Held(GO:0044305)
0.0 3.2 GO:0005643 nuclear pore(GO:0005643)
0.0 3.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.0 GO:0043679 axon terminus(GO:0043679)
0.3 2.7 GO:0097427 microtubule bundle(GO:0097427)
0.0 2.7 GO:0005776 autophagosome(GO:0005776)
0.5 2.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 2.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 2.4 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 2.2 GO:0044297 cell body(GO:0044297)
0.1 2.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 2.1 GO:0043194 axon initial segment(GO:0043194)
0.0 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 1.9 GO:0000172 ribonuclease MRP complex(GO:0000172)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 24.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 5.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 4.6 GO:0042169 SH2 domain binding(GO:0042169)
0.1 4.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 4.0 GO:0016779 nucleotidyltransferase activity(GO:0016779)
1.3 3.9 GO:0005436 sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 3.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 3.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 3.1 GO:0001848 complement binding(GO:0001848)
0.1 3.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 3.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 2.9 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 2.7 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.4 2.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 2.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.5 2.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 2.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.4 2.2 GO:0016936 galactoside binding(GO:0016936)
0.1 2.2 GO:0008139 nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 20.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 6.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 0.5 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.5 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 22.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 8.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.4 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 4.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 3.6 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.3 3.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 3.0 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 3.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.6 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.0 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.0 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.9 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 1.8 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling