Motif ID: Hoxa4

Z-value: 0.864


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Showing 1 to 20 of 194 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 12.830 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr4_+_144892813 4.101 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_70563435 3.750 ENSMUST00000123330.1
 Gad1
glutamate decarboxylase 1
chr7_-_19699008 3.732 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr4_+_144893077 3.289 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 2.968 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr18_-_31949571 2.863 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr12_+_38780284 2.555 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr2_-_77519565 2.415 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr6_+_8949670 2.393 ENSMUST00000060369.3
 Nxph1
neurexophilin 1
chr1_-_190170671 2.178 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr17_+_39846958 2.123 ENSMUST00000182010.1
 Gm26924
predicted gene, 26924
chr3_-_80802789 2.084 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr12_+_38780817 2.062 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_+_5218546 2.060 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr2_+_170731807 1.774 ENSMUST00000029075.4
 Dok5
docking protein 5
chr3_+_86070915 1.772 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr3_+_5218516 1.662 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr19_-_28967794 1.637 ENSMUST00000162110.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr3_+_5218589 1.429 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 12.8 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.9 10.0 GO:0042572 retinol metabolic process(GO:0042572)
0.7 7.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.5 3.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.2 3.7 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.4 2.9 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 2.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.2 2.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 2.4 GO:0070207 protein homotrimerization(GO:0070207)
0.7 2.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 2.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 1.3 GO:0021759 globus pallidus development(GO:0021759)
0.0 1.3 GO:0007050 cell cycle arrest(GO:0007050)
0.2 1.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 1.2 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.2 1.1 GO:0030916 otic vesicle formation(GO:0030916) semicircular canal morphogenesis(GO:0048752)
0.1 1.1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 1.1 GO:0008340 determination of adult lifespan(GO:0008340)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 3.5 GO:0060077 inhibitory synapse(GO:0060077)
0.6 2.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 2.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 0.9 GO:0044308 axonal spine(GO:0044308)
0.0 0.8 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)
0.2 0.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0051286 cell tip(GO:0051286)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0003682 chromatin binding(GO:0003682)
1.5 10.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 8.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 3.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.2 3.7 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.4 3.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 2.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 2.4 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 2.4 GO:0002039 p53 binding(GO:0002039)
0.2 2.0 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 1.3 GO:0003785 actin monomer binding(GO:0003785)
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.3 1.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 1.0 GO:0051959 dynein light intermediate chain binding(GO:0051959)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 10.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 7.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 2.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.6 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.6 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 3.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 3.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.0 2.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.4 2.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 0.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.5 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 0.4 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection