Motif ID: Hoxa6
Z-value: 0.751

Transcription factors associated with Hoxa6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxa6 | ENSMUSG00000043219.8 | Hoxa6 |
Top targets:
Showing 1 to 20 of 191 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 80 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.4 | 22.2 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
0.9 | 14.1 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
1.3 | 10.2 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
0.9 | 8.1 | GO:0048664 | neuron fate determination(GO:0048664) |
2.0 | 8.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
1.3 | 7.9 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
0.7 | 5.1 | GO:0019532 | oxalate transport(GO:0019532) |
1.2 | 4.8 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.1 | 4.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.6 | 4.3 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.2 | 4.1 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
0.2 | 3.4 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
0.3 | 3.2 | GO:0002118 | aggressive behavior(GO:0002118) |
0.4 | 3.0 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
0.0 | 2.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.3 | 2.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
0.2 | 2.4 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.8 | 2.3 | GO:0048389 | BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) negative regulation of immature T cell proliferation in thymus(GO:0033088) cloaca development(GO:0035844) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) metanephric S-shaped body morphogenesis(GO:0072284) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) cardiac jelly development(GO:1905072) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) |
0.0 | 2.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
0.0 | 2.2 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 24 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 16.6 | GO:0005667 | transcription factor complex(GO:0005667) |
0.1 | 16.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.3 | 7.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.4 | 3.9 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.0 | 3.5 | GO:0005681 | spliceosomal complex(GO:0005681) |
1.1 | 3.4 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
0.1 | 2.4 | GO:0098644 | complex of collagen trimers(GO:0098644) |
0.5 | 2.2 | GO:0008623 | CHRAC(GO:0008623) |
0.5 | 1.9 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
0.2 | 1.8 | GO:0033269 | internode region of axon(GO:0033269) |
0.2 | 1.1 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 1.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.0 | 0.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
0.1 | 0.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.1 | 0.8 | GO:0071439 | clathrin complex(GO:0071439) |
0.1 | 0.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.2 | 0.7 | GO:0042567 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567) |
0.1 | 0.7 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
0.0 | 0.7 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 52 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 19.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 16.7 | GO:0003682 | chromatin binding(GO:0003682) |
1.3 | 10.2 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
1.3 | 8.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.6 | 7.9 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
0.2 | 6.0 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.5 | 5.1 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.0 | 4.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.2 | 4.1 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
0.8 | 3.4 | GO:0050436 | microfibril binding(GO:0050436) |
0.1 | 3.0 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
0.1 | 2.5 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
0.0 | 2.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.3 | 2.3 | GO:0039706 | co-receptor binding(GO:0039706) |
0.4 | 1.9 | GO:0050816 | phosphothreonine binding(GO:0050816) |
0.1 | 1.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.1 | 1.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.2 | 1.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.1 | 1.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.3 | 1.2 | GO:0019808 | polyamine binding(GO:0019808) |
Gene overrepresentation in C2:CP category:
Showing 1 to 14 of 14 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 20.1 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.0 | 6.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.1 | 4.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.1 | 3.8 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.1 | 3.6 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.1 | 3.0 | PID_BMP_PATHWAY | BMP receptor signaling |
0.1 | 2.4 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.1 | 1.9 | PID_MYC_PATHWAY | C-MYC pathway |
0.0 | 1.4 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.1 | 1.1 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.0 | 1.0 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 0.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 0.6 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
0.0 | 0.2 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 24 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 8.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.1 | 6.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.1 | 4.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.1 | 3.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
0.2 | 2.4 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 1.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.0 | 1.4 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 1.3 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.1 | 1.2 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
0.1 | 0.9 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.1 | 0.9 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.1 | 0.9 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.0 | 0.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 0.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.0 | 0.7 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.7 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
0.0 | 0.7 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
0.0 | 0.6 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
0.1 | 0.5 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.0 | 0.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |