Motif ID: Hoxa6

Z-value: 0.751


Transcription factors associated with Hoxa6:

Gene SymbolEntrez IDGene Name
Hoxa6 ENSMUSG00000043219.8 Hoxa6



Activity profile for motif Hoxa6.

activity profile for motif Hoxa6


Sorted Z-values histogram for motif Hoxa6

Sorted Z-values for motif Hoxa6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa6

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 22.238 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr8_-_46294592 10.727 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr19_-_59170978 10.238 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr1_-_163313661 8.138 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr14_-_118052235 7.867 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr6_+_15185203 6.151 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr2_-_36104060 4.770 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr15_-_8710734 4.701 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_70474923 4.140 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr5_-_123141067 4.128 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr13_-_103764502 3.541 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr16_+_42907563 3.444 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr14_-_48665098 3.408 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr15_-_8710409 3.261 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_42583628 3.167 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_+_20737306 3.166 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr4_+_11579647 3.127 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chr4_-_14621805 2.545 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr14_-_122451109 2.524 ENSMUST00000081580.2
Gm5089
predicted gene 5089
chr8_-_84773381 2.493 ENSMUST00000109764.1
Nfix
nuclear factor I/X

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.4 22.2 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.9 14.1 GO:0097154 GABAergic neuron differentiation(GO:0097154)
1.3 10.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.9 8.1 GO:0048664 neuron fate determination(GO:0048664)
2.0 8.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 7.9 GO:0006570 tyrosine metabolic process(GO:0006570)
0.7 5.1 GO:0019532 oxalate transport(GO:0019532)
1.2 4.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 4.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.6 4.3 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.2 4.1 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.2 3.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.3 3.2 GO:0002118 aggressive behavior(GO:0002118)
0.4 3.0 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 2.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.3 2.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 2.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.8 2.3 GO:0048389 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) negative regulation of immature T cell proliferation in thymus(GO:0033088) cloaca development(GO:0035844) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) metanephric S-shaped body morphogenesis(GO:0072284) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) cardiac jelly development(GO:1905072) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.0 2.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.2 GO:0006261 DNA-dependent DNA replication(GO:0006261)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 16.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 7.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 3.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 3.5 GO:0005681 spliceosomal complex(GO:0005681)
1.1 3.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 2.4 GO:0098644 complex of collagen trimers(GO:0098644)
0.5 2.2 GO:0008623 CHRAC(GO:0008623)
0.5 1.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 1.8 GO:0033269 internode region of axon(GO:0033269)
0.2 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 0.7 GO:0042567 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 16.7 GO:0003682 chromatin binding(GO:0003682)
1.3 10.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.3 8.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 7.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 6.0 GO:0071837 HMG box domain binding(GO:0071837)
0.5 5.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 4.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 4.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.8 3.4 GO:0050436 microfibril binding(GO:0050436)
0.1 3.0 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 2.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 2.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 2.3 GO:0039706 co-receptor binding(GO:0039706)
0.4 1.9 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 1.2 GO:0019808 polyamine binding(GO:0019808)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 6.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 3.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 3.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.9 PID_MYC_PATHWAY C-MYC pathway
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 6.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.6 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 2.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 0.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 0.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors