Motif ID: Hoxa7_Hoxc8

Z-value: 0.514

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 5.353 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr5_-_62766153 4.148 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_137169710 3.657 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chrX_-_143933089 3.035 ENSMUST00000087313.3
 Dcx
doublecortin
chr14_-_100149764 2.172 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr7_-_46667375 2.161 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr3_+_5218516 1.930 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chrX_-_143933204 1.533 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr17_-_45659312 1.480 ENSMUST00000120717.1
 Capn11
calpain 11
chr9_-_55919605 1.350 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr6_-_118479237 1.307 ENSMUST00000161170.1
 Zfp9
zinc finger protein 9
chr2_+_69897255 1.216 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr2_+_116067213 1.199 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr17_+_88440711 1.128 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr1_-_134955847 1.037 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr10_-_117148474 0.970 ENSMUST00000020381.3
 Frs2
fibroblast growth factor receptor substrate 2
chr15_-_8710409 0.954 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_116067391 0.900 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr9_-_103228420 0.874 ENSMUST00000126359.1
 Trf
transferrin
chr3_+_5218589 0.859 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 4.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 2.9 GO:0030308 negative regulation of cell growth(GO:0030308)
0.3 2.2 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.5 2.0 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.4 1.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 1.0 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.9 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.2 0.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 0.7 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 0.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.4 GO:0042581 specific granule(GO:0042581)
0.0 3.0 GO:0030426 growth cone(GO:0030426)
0.0 1.8 GO:0031672 A band(GO:0031672)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 0.9 GO:0097433 dense body(GO:0097433)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 0.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0008017 microtubule binding(GO:0008017)
0.1 4.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.9 GO:0003924 GTPase activity(GO:0003924)
0.7 2.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.2 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 2.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.0 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.2 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle