Motif ID: Hoxb13

Z-value: 0.800


Transcription factors associated with Hoxb13:

Gene SymbolEntrez IDGene Name
Hoxb13 ENSMUSG00000049604.3 Hoxb13



Activity profile for motif Hoxb13.

activity profile for motif Hoxb13


Sorted Z-values histogram for motif Hoxb13

Sorted Z-values for motif Hoxb13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb13

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_-_1286563 3.045 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr8_+_12395287 2.776 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr16_+_30065333 2.655 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr9_+_65890237 2.629 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr12_+_117843873 2.611 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr18_-_78206408 2.255 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr3_+_106034661 2.216 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr5_+_75075464 2.208 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr11_+_120948480 2.196 ENSMUST00000070653.6
 Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr7_+_4119525 2.175 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 2.155 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr5_+_140607334 2.126 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_91269759 2.097 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr9_-_63711969 2.042 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr9_-_54661870 2.041 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr5_-_135251209 2.030 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr3_-_150073620 1.975 ENSMUST00000057740.5
 Rpsa-ps10
ribosomal protein SA, pseudogene 10
chrY_+_897782 1.903 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr14_-_47411666 1.842 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr10_+_84756055 1.833 ENSMUST00000060397.6
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 322 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0046847 filopodium assembly(GO:0046847)
0.1 3.7 GO:1902808 positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.2 3.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 3.5 GO:0006284 base-excision repair(GO:0006284)
0.3 2.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.9 2.7 GO:0021557 oculomotor nerve development(GO:0021557)
0.7 2.7 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.8 2.5 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.2 2.4 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 2.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.8 2.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.3 2.3 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.4 2.2 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.3 2.2 GO:0042148 strand invasion(GO:0042148)
0.0 2.2 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.4 2.1 GO:0007386 compartment pattern specification(GO:0007386)
0.3 2.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.7 2.0 GO:0044413 regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.7 2.0 GO:1990523 bone regeneration(GO:1990523)
0.7 2.0 GO:0006597 spermine biosynthetic process(GO:0006597)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 4.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 4.0 GO:0005925 focal adhesion(GO:0005925)
0.0 3.6 GO:0001650 fibrillar center(GO:0001650)
0.0 3.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.0 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.1 2.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.8 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 2.6 GO:0005657 replication fork(GO:0005657)
0.6 2.3 GO:0008623 CHRAC(GO:0008623)
0.1 2.3 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 2.2 GO:0000776 kinetochore(GO:0000776)
0.0 2.1 GO:0016459 myosin complex(GO:0016459)
0.4 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 2.0 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 1.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 1.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 1.7 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 5.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.1 4.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.6 3.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.4 3.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 2.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 2.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.7 GO:0071837 HMG box domain binding(GO:0071837)
0.8 2.5 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.4 2.3 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.3 2.2 GO:0000150 recombinase activity(GO:0000150)
0.1 2.2 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.7 2.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 2.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 2.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 2.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.5 2.0 GO:0019808 polyamine binding(GO:0019808)
0.4 2.0 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.2 2.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_FGF_PATHWAY FGF signaling pathway
0.1 4.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 3.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.4 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 2.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 1.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 4.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 4.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 3.4 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.1 2.9 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 2.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 2.5 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 2.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 2.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 2.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 2.0 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME_DNA_STRAND_ELONGATION Genes involved in DNA strand elongation
0.1 2.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.5 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis