Motif ID: Hoxb7

Z-value: 3.747


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_42907563 31.886 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr16_+_43247278 27.053 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20

chr1_+_19103022 26.070 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chrX_-_43167817 24.564 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr8_+_54954728 23.891 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr13_+_83504032 22.091 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr15_+_21111452 21.727 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_13839916 20.756 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr3_+_55461758 20.652 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr2_-_7396192 20.581 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr2_+_65930117 20.322 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr3_+_55782500 20.270 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr11_-_30198232 20.022 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr5_+_117841839 19.952 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr17_-_81649607 19.927 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr1_+_66321708 19.377 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr6_-_136171722 19.296 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr19_+_26605106 18.792 ENSMUST00000025862.7
ENSMUST00000176030.1
 Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr15_+_18818895 18.768 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr16_+_7069825 18.648 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 450 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 130.3 GO:0007416 synapse assembly(GO:0007416)
2.8 116.8 GO:0006376 mRNA splice site selection(GO:0006376)
2.3 95.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
7.1 77.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
7.1 64.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.9 59.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.4 53.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
2.8 47.3 GO:0097090 presynaptic membrane organization(GO:0097090)
3.6 46.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
3.3 45.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
5.5 44.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
4.3 39.1 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
6.3 37.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
7.2 36.2 GO:0046684 response to pyrethroid(GO:0046684)
1.5 35.3 GO:0002076 osteoblast development(GO:0002076)
1.3 35.0 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
3.3 33.0 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
1.4 33.0 GO:0008090 retrograde axonal transport(GO:0008090)
3.6 32.4 GO:0071420 cellular response to histamine(GO:0071420)
10.4 31.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 201.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 97.7 GO:0060076 excitatory synapse(GO:0060076)
4.0 80.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 77.0 GO:0016021 integral component of membrane(GO:0016021)
1.6 65.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 64.7 GO:0005887 integral component of plasma membrane(GO:0005887)
3.4 64.0 GO:0071564 npBAF complex(GO:0071564)
0.5 54.7 GO:0000118 histone deacetylase complex(GO:0000118)
5.8 52.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
3.4 50.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.5 45.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
4.9 44.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.9 40.8 GO:0031430 M band(GO:0031430)
2.0 39.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.6 38.5 GO:0043083 synaptic cleft(GO:0043083)
2.1 35.9 GO:0031045 dense core granule(GO:0031045)
2.2 32.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 31.0 GO:0030425 dendrite(GO:0030425)
2.4 30.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
7.4 29.6 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 279 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 118.4 GO:0036002 pre-mRNA binding(GO:0036002)
2.0 113.4 GO:0030507 spectrin binding(GO:0030507)
0.4 110.9 GO:0008017 microtubule binding(GO:0008017)
0.5 83.2 GO:0004386 helicase activity(GO:0004386)
2.2 64.0 GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
1.8 58.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 53.6 GO:0003714 transcription corepressor activity(GO:0003714)
6.5 52.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.7 50.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.8 48.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.4 41.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
6.7 40.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 36.4 GO:0005262 calcium channel activity(GO:0005262)
1.5 35.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 34.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
2.1 34.2 GO:0004385 guanylate kinase activity(GO:0004385)
1.9 33.8 GO:0004890 GABA-A receptor activity(GO:0004890)
1.6 32.5 GO:0030506 ankyrin binding(GO:0030506)
0.3 32.4 GO:0005057 receptor signaling protein activity(GO:0005057)
3.1 31.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 67.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.8 62.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.8 49.7 PID_LKB1_PATHWAY LKB1 signaling events
0.9 46.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
1.3 46.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.4 44.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.8 34.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.6 29.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.5 26.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 26.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.8 25.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.5 22.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.5 22.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.6 21.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.4 20.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.4 18.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.4 15.4 PID_FGF_PATHWAY FGF signaling pathway
0.6 14.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.4 13.2 PID_ALK1_PATHWAY ALK1 signaling events
0.3 12.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 122.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.8 78.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.7 54.5 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
1.3 47.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.1 46.6 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
1.6 42.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.1 39.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
2.1 33.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
3.2 32.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.0 27.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 26.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.8 25.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
1.8 23.7 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.6 23.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.0 22.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
1.1 21.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 17.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.7 17.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
3.8 15.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.5 11.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions