Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.595

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:

Gene SymbolEntrez IDGene Name
Arx ENSMUSG00000035277.9 Arx
Esx1 ENSMUSG00000023443.7 Esx1
Hoxc4 ENSMUSG00000075394.3 Hoxc4
Otp ENSMUSG00000021685.10 Otp
Phox2b ENSMUSG00000012520.8 Phox2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otpmm10_v2_chr13_+_94875600_948756110.417.5e-03Click!
Arxmm10_v2_chrX_+_93286499_932865220.352.7e-02Click!


Activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b.

activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b


Sorted Z-values histogram for motif Hoxc4_Arx_Otp_Esx1_Phox2b

Sorted Z-values for motif Hoxc4_Arx_Otp_Esx1_Phox2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_8948608 5.727 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr17_-_48432723 4.440 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_+_119063429 4.390 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_+_20737306 4.126 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chrX_-_60893430 3.955 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr10_-_37138863 2.690 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr2_-_168767136 2.602 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr13_-_102906046 2.501 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_+_105789869 2.416 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr13_-_100786402 2.360 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr10_+_37139558 2.357 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr8_-_61902669 2.279 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr13_-_58354862 2.236 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr13_-_102905740 2.151 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr19_-_29334646 2.091 ENSMUST00000044143.5
 Rln1
relaxin 1
chr15_-_67113909 1.943 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr2_-_168767029 1.874 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr4_-_14621805 1.691 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr4_+_145585166 1.619 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr15_-_64922290 1.611 ENSMUST00000023007.5
 Adcy8
adenylate cyclase 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0048706 embryonic skeletal system development(GO:0048706)
0.2 4.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.5 4.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 4.1 GO:0051693 actin filament capping(GO:0051693)
0.2 4.0 GO:0007530 sex determination(GO:0007530)
0.0 4.0 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.5 3.6 GO:0019532 oxalate transport(GO:0019532)
0.1 2.7 GO:0051764 actin crosslink formation(GO:0051764)
0.8 2.4 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 2.3 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.1 2.2 GO:0021591 ventricular system development(GO:0021591)
0.5 2.1 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.0 2.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) long-term memory(GO:0007616)
0.2 1.5 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.0 1.5 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.1 1.3 GO:0036376 sodium ion export from cell(GO:0036376)
0.4 1.2 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2 1.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0000792 heterochromatin(GO:0000792)
0.9 2.7 GO:0042585 germinal vesicle(GO:0042585)
0.6 2.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 2.3 GO:0002102 podosome(GO:0002102)
0.0 2.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.8 GO:0043034 costamere(GO:0043034)
0.1 1.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 1.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 1.0 GO:0097422 tubular endosome(GO:0097422)
0.1 1.0 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.9 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.7 GO:0030286 dynein complex(GO:0030286)
0.2 0.6 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.6 GO:0034709 methylosome(GO:0034709)
0.1 0.5 GO:0060187 cell pole(GO:0060187)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.0 GO:0051015 actin filament binding(GO:0051015)
1.1 4.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 4.4 GO:0000287 magnesium ion binding(GO:0000287)
0.1 4.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 3.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 2.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 2.1 GO:0005179 hormone activity(GO:0005179)
0.5 1.9 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 1.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 1.6 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.3 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 1.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.4 1.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.4 1.2 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 1.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 1.0 GO:0034452 dynactin binding(GO:0034452)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0031957 fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.9 GO:0019842 vitamin binding(GO:0019842)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 2.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 1.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 1.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 1.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors