Motif ID: Hoxc9

Z-value: 0.760


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.105.5e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Showing 1 to 20 of 63 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 3.669 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr13_+_94083490 3.616 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr1_+_58210397 3.520 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr4_+_144893127 3.393 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_-_26516620 3.279 ENSMUST00000132820.1
 Notch1
notch 1
chr9_+_35423582 3.259 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr2_+_4300462 3.040 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr16_-_37384915 3.020 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr2_+_70474923 2.976 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr1_-_45503282 2.628 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr4_+_107830958 2.466 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr8_-_120228221 2.137 ENSMUST00000183235.1
 A330074K22Rik
RIKEN cDNA A330074K22 gene
chr16_-_37384940 2.044 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr18_+_65582239 2.019 ENSMUST00000182684.1
 Zfp532
zinc finger protein 532
chrX_-_141474034 1.885 ENSMUST00000101205.2
 Col4a6
collagen, type IV, alpha 6
chr17_-_49564262 1.817 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr4_+_100776664 1.801 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr3_+_66985680 1.386 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chrX_+_56609751 1.332 ENSMUST00000144068.1
 Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr10_+_4710119 1.311 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.9 4.5 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.1 3.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.2 3.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.3 3.4 GO:0042572 retinol metabolic process(GO:0042572)
1.1 3.3 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.4 3.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 3.0 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 3.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.9 2.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 2.5 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 1.9 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 1.9 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 1.3 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.4 1.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 1.2 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 1.1 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.5 GO:0005915 zonula adherens(GO:0005915)
0.3 3.7 GO:0042581 specific granule(GO:0042581)
0.7 3.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 2.7 GO:0005923 bicellular tight junction(GO:0005923)
0.9 2.6 GO:0005588 collagen type V trimer(GO:0005588)
0.0 2.1 GO:0005875 microtubule associated complex(GO:0005875)
0.4 1.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 1.2 GO:0044308 axonal spine(GO:0044308)
0.2 0.9 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.4 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.2 GO:0071914 prominosome(GO:0071914)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0045296 cadherin binding(GO:0045296)
0.0 5.1 GO:0019905 syntaxin binding(GO:0019905)
0.9 3.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.5 3.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.3 GO:0005112 Notch binding(GO:0005112)
0.0 2.7 GO:0030674 protein binding, bridging(GO:0030674)
0.6 2.5 GO:0038025 reelin receptor activity(GO:0038025)
0.1 2.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.4 1.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 1.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 1.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.4 1.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.9 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.9 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.5 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 4.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 3.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.5 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction