Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.825

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893127 10.653 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_-_84064772 10.311 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144892813 7.147 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_+_159737510 6.144 ENSMUST00000111669.3
 Tnr
tenascin R
chr4_+_144893077 5.683 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr17_+_3397189 4.790 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr5_-_62766153 4.576 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_+_80018877 3.692 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4



chr3_-_49757257 3.663 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr1_+_19103022 3.647 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr4_-_154636831 3.376 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr3_+_62419668 3.359 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr18_+_69593361 3.344 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr7_-_142661858 3.160 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr7_-_73537621 3.021 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr1_-_56969864 2.927 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr3_+_66985680 2.718 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr17_+_31433054 2.612 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr4_-_88033328 2.539 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_56969827 2.532 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 23.5 GO:0042572 retinol metabolic process(GO:0042572)
1.5 6.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 5.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 4.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 4.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 3.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.2 3.7 GO:1901629 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of presynaptic membrane organization(GO:1901629)
0.4 3.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 3.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 3.3 GO:0042118 endothelial cell activation(GO:0042118)
0.8 3.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.4 3.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 3.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.2 3.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 2.5 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 2.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 2.3 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 2.2 GO:0090527 actin filament reorganization(GO:0090527)
0.1 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 6.1 GO:0072534 perineuronal net(GO:0072534)
0.1 5.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 4.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 3.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 3.2 GO:0016235 aggresome(GO:0016235)
0.0 2.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.4 GO:0000790 nuclear chromatin(GO:0000790)
0.1 2.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.2 GO:0001726 ruffle(GO:0001726)
0.1 2.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 2.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.7 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.3 1.4 GO:0070820 tertiary granule(GO:0070820)
0.3 1.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.0 GO:0009986 cell surface(GO:0009986)
0.1 0.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.9 GO:0001739 sex chromatin(GO:0001739)
0.0 0.9 GO:0001917 photoreceptor inner segment(GO:0001917)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 23.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 6.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.4 6.1 GO:0046625 sphingolipid binding(GO:0046625)
0.1 5.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 4.5 GO:0046332 SMAD binding(GO:0046332)
0.0 3.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 3.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.8 3.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 3.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 3.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 3.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.9 GO:0030507 spectrin binding(GO:0030507)
0.6 2.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 2.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 2.1 GO:0031402 sodium ion binding(GO:0031402)
0.2 1.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 1.5 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 21.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 3.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.9 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.9 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 3.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.2 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.1 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 1.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling