Motif ID: Hoxd8

Z-value: 0.530


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138848576 1.749 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr6_+_34384218 1.198 ENSMUST00000038383.7
ENSMUST00000115051.1
 Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr10_+_97482350 1.041 ENSMUST00000163448.2
 Dcn
decorin
chr3_+_94372794 1.040 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr17_-_48432723 1.035 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr3_+_127633134 0.978 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr2_-_140671462 0.975 ENSMUST00000110057.2
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr2_-_140671400 0.880 ENSMUST00000056760.3
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_-_172027269 0.753 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr11_+_117809687 0.707 ENSMUST00000120928.1
ENSMUST00000175737.1
 Syngr2

synaptogyrin 2

chr6_+_71282280 0.665 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr2_-_160619971 0.575 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr15_-_35155750 0.572 ENSMUST00000067033.7
ENSMUST00000018476.7
 Stk3

serine/threonine kinase 3

chr12_-_84617326 0.556 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr18_+_11633276 0.548 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr11_+_117809653 0.524 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
 Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr1_-_158814469 0.492 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr19_+_24875679 0.444 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr9_+_54538984 0.434 ENSMUST00000060242.5
ENSMUST00000118413.1
 Sh2d7

SH2 domain containing 7

chr10_-_127030813 0.412 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.9 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.4 1.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 1.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 1.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 1.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.3 0.8 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.6 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.4 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.3 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.0 GO:0098644 complex of collagen trimers(GO:0098644)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.0 0.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.3 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0045499 chemorepellent activity(GO:0045499)
0.2 1.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 1.0 GO:0008142 oxysterol binding(GO:0008142)
0.3 1.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.3 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex