Motif ID: Hoxd9

Z-value: 0.732


Transcription factors associated with Hoxd9:

Gene SymbolEntrez IDGene Name
Hoxd9 ENSMUSG00000043342.8 Hoxd9



Activity profile for motif Hoxd9.

activity profile for motif Hoxd9


Sorted Z-values histogram for motif Hoxd9

Sorted Z-values for motif Hoxd9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd9

PNG image of the network

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Top targets:


Showing 1 to 20 of 91 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_116129615 6.084 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr18_-_78206408 4.378 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr6_-_36811361 4.258 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr4_+_136143497 4.070 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr7_+_66365905 3.686 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chrX_+_82948861 3.248 ENSMUST00000114000.1
 Dmd
dystrophin, muscular dystrophy
chr15_-_65014904 2.624 ENSMUST00000110100.2
 Gm21961
predicted gene, 21961
chr16_-_45693658 2.560 ENSMUST00000114562.2
ENSMUST00000036617.7
 Tmprss7

transmembrane serine protease 7

chr17_-_32166879 2.512 ENSMUST00000087723.3
 Notch3
notch 3
chr3_-_66296807 2.313 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chrX_+_85048309 2.049 ENSMUST00000113991.1
ENSMUST00000113992.2
 Dmd

dystrophin, muscular dystrophy

chr8_+_84723003 2.040 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr13_-_105271039 1.940 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr17_-_78684262 1.925 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr11_-_109472611 1.801 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr11_+_29373618 1.767 ENSMUST00000040182.6
ENSMUST00000109477.1
 Ccdc88a

coiled coil domain containing 88A

chr2_-_58052832 1.751 ENSMUST00000090940.5
 Ermn
ermin, ERM-like protein
chr15_-_37459327 1.468 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr1_-_163289214 1.339 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr3_-_49757257 1.320 ENSMUST00000035931.7
 Pcdh18
protocadherin 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.1 GO:0061032 visceral serous pericardium development(GO:0061032)
1.8 5.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.5 4.4 GO:0071918 urea transmembrane transport(GO:0071918)
1.4 4.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 4.1 GO:0030903 notochord development(GO:0030903)
0.0 3.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 2.5 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.0 2.2 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.1 2.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 1.9 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.4 1.8 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 1.8 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 1.6 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 1.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 1.3 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 1.2 GO:0035989 tendon development(GO:0035989)
0.0 1.1 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.3 1.0 GO:0036292 DNA rewinding(GO:0036292)
0.1 1.0 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0002102 podosome(GO:0002102)
0.3 5.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 4.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.0 1.9 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2 1.8 GO:0033269 internode region of axon(GO:0033269)
0.0 1.6 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.4 1.2 GO:1990423 RZZ complex(GO:1990423)
0.1 1.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 1.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.7 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0042641 actomyosin(GO:0042641)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 6.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 5.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 4.8 GO:0003779 actin binding(GO:0003779)
0.7 4.4 GO:0015204 urea transmembrane transporter activity(GO:0015204)
1.4 4.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 4.1 GO:0005504 fatty acid binding(GO:0005504)
0.0 2.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 2.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.8 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 1.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 1.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 1.0 GO:0004686 elongation factor-2 kinase activity(GO:0004686)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 4.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 2.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.7 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 0.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 5.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 3.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 2.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.0 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.8 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.7 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)