Motif ID: Hsf2

Z-value: 1.780


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_57486414-0.287.2e-02Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 11.349 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr17_-_25797032 10.534 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr10_+_4710119 10.303 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr10_-_78591945 9.560 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr9_+_44134562 9.498 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr10_+_84838143 9.229 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr11_-_89302545 9.028 ENSMUST00000061728.3
 Nog
noggin
chr1_-_72874877 8.911 ENSMUST00000027377.8
 Igfbp5
insulin-like growth factor binding protein 5
chr17_-_70851189 8.857 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr18_-_80986578 8.364 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr17_-_70849644 8.233 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr12_-_91746020 7.314 ENSMUST00000166967.1
 Ston2
stonin 2
chr11_-_11970540 7.121 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr1_-_133424377 6.849 ENSMUST00000153799.1
 Sox13
SRY-box containing gene 13
chr10_-_92164666 6.796 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr7_+_16781341 6.486 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr5_-_5514730 6.333 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr9_+_7764041 6.298 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123
chr14_-_48667508 6.143 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr6_-_92943485 6.137 ENSMUST00000113438.1
 Adamts9
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 236 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 21.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.0 20.1 GO:2000981 negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.4 12.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
2.6 10.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 10.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.6 9.7 GO:0021891 olfactory bulb interneuron development(GO:0021891)
1.9 9.6 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.5 9.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.8 9.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.4 9.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
2.3 9.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
1.3 8.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 7.9 GO:0045793 positive regulation of cell size(GO:0045793)
0.6 7.7 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.8 7.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 6.7 GO:0061077 chaperone-mediated protein folding(GO:0061077)
1.5 6.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 6.1 GO:1902913 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of neuroepithelial cell differentiation(GO:1902913)
0.2 6.1 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) negative regulation of cell cycle G2/M phase transition(GO:1902750)
1.5 6.0 GO:0015825 L-serine transport(GO:0015825)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 12.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 10.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
1.5 10.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 9.4 GO:0009986 cell surface(GO:0009986)
2.2 8.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.6 8.6 GO:0030061 mitochondrial crista(GO:0030061)
0.9 7.3 GO:0005818 aster(GO:0005818)
0.1 6.8 GO:0016459 myosin complex(GO:0016459)
0.3 6.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 6.5 GO:0031985 Golgi cisterna(GO:0031985)
0.1 5.9 GO:0005882 intermediate filament(GO:0005882)
0.0 5.8 GO:0016607 nuclear speck(GO:0016607)
0.1 5.6 GO:0030315 T-tubule(GO:0030315)
0.1 5.6 GO:0000790 nuclear chromatin(GO:0000790)
0.1 5.5 GO:0005604 basement membrane(GO:0005604)
0.0 5.3 GO:0005802 trans-Golgi network(GO:0005802)
0.5 5.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 5.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 5.1 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0 21.2 GO:0070410 co-SMAD binding(GO:0070410)
0.7 12.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 11.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 11.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
3.4 10.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.7 9.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
1.1 8.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 8.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 7.6 GO:0019955 cytokine binding(GO:0019955)
0.8 7.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.5 7.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 6.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 6.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 6.5 GO:0003735 structural constituent of ribosome(GO:0003735)
1.5 5.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.7 5.8 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.8 5.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 5.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 5.1 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 35.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 14.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 13.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 12.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 11.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 10.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 9.1 PID_BMP_PATHWAY BMP receptor signaling
0.1 8.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 8.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.7 PID_ATM_PATHWAY ATM pathway
0.2 7.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 6.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 6.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 5.4 PID_CDC42_PATHWAY CDC42 signaling events
0.3 5.2 PID_BARD1_PATHWAY BARD1 signaling events
0.2 5.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 5.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 4.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 21.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 12.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 11.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 11.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 10.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 9.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 9.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 9.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.6 8.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 7.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 5.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.6 5.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 5.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 5.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.2 5.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 5.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 5.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 4.9 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 4.9 REACTOME_MYOGENESIS Genes involved in Myogenesis