Motif ID: Hsf4
Z-value: 0.820
Transcription factors associated with Hsf4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hsf4 | ENSMUSG00000033249.4 | Hsf4 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 134 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.6 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.7 | 4.4 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.7 | 2.8 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.9 | 2.6 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.8 | 2.3 | GO:0035799 | ureter maturation(GO:0035799) |
| 0.4 | 2.1 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.2 | 2.1 | GO:1902018 | regulation of mitotic spindle assembly(GO:1901673) negative regulation of cilium assembly(GO:1902018) |
| 0.5 | 2.0 | GO:0060715 | syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715) |
| 0.3 | 1.8 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
| 0.2 | 1.8 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 1.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 1.7 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 1.7 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.1 | 1.4 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.3 | 1.3 | GO:1901252 | regulation of intracellular transport of viral material(GO:1901252) |
| 0.1 | 1.3 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 1.3 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.4 | 1.2 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.2 | 1.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.2 | 1.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 63 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.4 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.1 | 3.9 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.2 | 2.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 2.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.2 | GO:0030017 | sarcomere(GO:0030017) |
| 0.3 | 2.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 1.8 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 1.4 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 1.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 1.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 1.2 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.2 | 1.1 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 1.1 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 1.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 1.0 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 1.0 | GO:0000800 | lateral element(GO:0000800) |
| 0.0 | 1.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 0.9 | GO:0000938 | GARP complex(GO:0000938) |
| 0.1 | 0.9 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 87 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.6 | 4.4 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.0 | 3.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.4 | 2.6 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.1 | 2.6 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 2.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.3 | 2.2 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 2.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.4 | 1.9 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.0 | 1.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 1.4 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 0.0 | 1.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 1.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 1.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.2 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.2 | 1.1 | GO:0035241 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) |
| 0.2 | 1.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.2 | 1.0 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.2 | 1.0 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 1.0 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 26 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 4.4 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 3.6 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.8 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.4 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.2 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.8 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.8 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 0.7 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.7 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.1 | 0.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 0.4 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.4 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.4 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.4 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 29 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.4 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 2.6 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.4 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.9 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 1.8 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 1.6 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 1.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.0 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.9 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.9 | REACTOME_RNA_POL_I_TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.8 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.8 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.8 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.8 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 0.7 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.7 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 0.6 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 0.6 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
