Motif ID: Id4

Z-value: 0.989


Transcription factors associated with Id4:

Gene SymbolEntrez IDGene Name
Id4 ENSMUSG00000021379.1 Id4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Id4mm10_v2_chr13_+_48261427_482614270.221.7e-01Click!


Activity profile for motif Id4.

activity profile for motif Id4


Sorted Z-values histogram for motif Id4

Sorted Z-values for motif Id4



Network of associatons between targets according to the STRING database.



First level regulatory network of Id4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_70562007 5.272 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr3_-_82145865 4.862 ENSMUST00000048976.6
 Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr2_+_70562147 4.802 ENSMUST00000148210.1
 Gad1
glutamate decarboxylase 1
chr14_-_103843685 4.741 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr11_-_67922136 4.459 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr15_-_66831625 4.409 ENSMUST00000164163.1
 Sla
src-like adaptor
chr16_+_91269759 4.314 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr19_+_36409719 4.057 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr3_+_145758674 3.907 ENSMUST00000029845.8
 Ddah1
dimethylarginine dimethylaminohydrolase 1
chr17_-_25570678 3.689 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr15_-_98677451 3.669 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr4_+_125490688 3.536 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr14_-_103844173 3.499 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr8_-_4217133 3.471 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr4_-_137766474 2.963 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr1_+_86045863 2.897 ENSMUST00000165824.1
 2810459M11Rik
RIKEN cDNA 2810459M11 gene
chr3_+_89436736 2.859 ENSMUST00000146630.1
ENSMUST00000145753.1
 Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr15_-_98004634 2.848 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr8_-_4217459 2.810 ENSMUST00000176227.1
 BC068157
cDNA sequence BC068157
chr7_+_126847908 2.805 ENSMUST00000147257.1
ENSMUST00000139174.1
 Doc2a

double C2, alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.4 7.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.5 6.3 GO:0060174 limb bud formation(GO:0060174)
1.1 5.7 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.3 5.4 GO:0060032 notochord regression(GO:0060032)
0.1 5.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.0 4.9 GO:0075136 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.4 4.8 GO:0000052 citrulline metabolic process(GO:0000052)
0.1 4.6 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.0 4.1 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 3.6 GO:0061157 mRNA destabilization(GO:0061157)
0.3 3.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.1 3.4 GO:0072034 renal vesicle induction(GO:0072034)
0.1 3.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.8 3.3 GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393)
0.6 3.3 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.2 3.3 GO:0016322 neuron remodeling(GO:0016322)
0.0 3.3 GO:0016579 protein deubiquitination(GO:0016579)
0.5 3.2 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
1.0 3.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.7 GO:0031965 nuclear membrane(GO:0031965)
0.3 10.1 GO:0060077 inhibitory synapse(GO:0060077)
0.1 9.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 6.2 GO:0005667 transcription factor complex(GO:0005667)
0.4 5.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.5 5.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 5.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.4 5.4 GO:0097542 ciliary tip(GO:0097542)
0.0 4.5 GO:0005923 bicellular tight junction(GO:0005923)
0.2 4.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.7 4.1 GO:0016011 dystroglycan complex(GO:0016011)
0.2 4.0 GO:1990635 proximal dendrite(GO:1990635)
0.0 3.8 GO:0005912 adherens junction(GO:0005912)
0.1 3.6 GO:0043596 nuclear replication fork(GO:0043596)
0.1 3.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 3.2 GO:0016528 sarcoplasm(GO:0016528)
0.0 3.2 GO:0031519 PcG protein complex(GO:0031519)
0.1 3.1 GO:0090544 BAF-type complex(GO:0090544)
0.7 3.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 9.9 GO:0003682 chromatin binding(GO:0003682)
2.7 8.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 6.3 GO:0003714 transcription corepressor activity(GO:0003714)
1.1 5.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 5.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.4 5.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.1 5.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 4.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 4.5 GO:0005096 GTPase activator activity(GO:0005096)
0.9 4.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 4.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.5 4.1 GO:0043237 laminin-1 binding(GO:0043237)
0.1 4.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 4.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 3.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 3.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 3.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 PID_ENDOTHELIN_PATHWAY Endothelins
0.3 9.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 7.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 6.1 NABA_COLLAGENS Genes encoding collagen proteins
0.6 4.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 4.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 3.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.0 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 3.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 2.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 8.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 6.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 5.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 4.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.7 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 4.6 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 4.6 REACTOME_ION_CHANNEL_TRANSPORT Genes involved in Ion channel transport
0.2 3.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 3.6 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.5 3.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 2.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events