Motif ID: Ikzf2

Z-value: 0.654


Transcription factors associated with Ikzf2:

Gene SymbolEntrez IDGene Name
Ikzf2 ENSMUSG00000025997.7 Ikzf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ikzf2mm10_v2_chr1_-_69685937_696859660.019.4e-01Click!


Activity profile for motif Ikzf2.

activity profile for motif Ikzf2


Sorted Z-values histogram for motif Ikzf2

Sorted Z-values for motif Ikzf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ikzf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 120 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 5.019 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr15_+_3270767 2.651 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr2_-_71546745 1.979 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr3_-_116129615 1.832 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr6_-_23248264 1.641 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_-_55419898 1.542 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr5_-_123141067 1.507 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chr1_-_45503282 1.344 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr6_+_15185203 1.280 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr6_+_4003926 1.274 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr12_+_75308308 1.206 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chrX_+_106920618 1.075 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr1_+_45311538 0.986 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr5_+_30913398 0.940 ENSMUST00000031055.5
 Emilin1
elastin microfibril interfacer 1
chr3_+_159839729 0.936 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr13_-_103764502 0.919 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr3_+_88214474 0.877 ENSMUST00000181356.1
ENSMUST00000181396.1
 Gm3764

predicted gene 3764

chr16_+_30065333 0.868 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr4_+_105157339 0.865 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr19_+_55894508 0.815 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.0 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.2 1.8 GO:0061032 visceral serous pericardium development(GO:0061032)
0.3 1.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.5 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.4 1.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.3 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 1.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 1.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 1.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 0.9 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.3 0.9 GO:0021557 oculomotor nerve development(GO:0021557)
0.0 0.9 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.8 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.8 GO:0051451 myoblast migration(GO:0051451)
0.1 0.7 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.0 0.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.7 GO:0021884 forebrain neuron development(GO:0021884)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0002102 podosome(GO:0002102)
0.4 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 1.3 GO:0005588 collagen type V trimer(GO:0005588)
0.0 1.1 GO:0032590 dendrite membrane(GO:0032590)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.8 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 0.7 GO:0071953 elastic fiber(GO:0071953)
0.1 0.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.6 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.4 GO:0032437 cuticular plate(GO:0032437)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.2 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.1 GO:0070888 E-box binding(GO:0070888)
0.5 1.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.1 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.2 1.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.8 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 0.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.6 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.4 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.4 REACTOME_SPHINGOLIPID_METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.1 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor