Motif ID: Insm1

Z-value: 0.490


Transcription factors associated with Insm1:

Gene SymbolEntrez IDGene Name
Insm1 ENSMUSG00000068154.4 Insm1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Insm1mm10_v2_chr2_+_146221921_1462219210.425.8e-03Click!


Activity profile for motif Insm1.

activity profile for motif Insm1


Sorted Z-values histogram for motif Insm1

Sorted Z-values for motif Insm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Insm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_156562141 2.461 ENSMUST00000175773.1
 Negr1
neuronal growth regulator 1
chr3_+_156561950 2.248 ENSMUST00000041425.5
ENSMUST00000106065.1
 Negr1

neuronal growth regulator 1

chr16_-_67620880 1.920 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr3_+_156561792 1.694 ENSMUST00000074015.4
 Negr1
neuronal growth regulator 1
chr6_+_4902913 1.692 ENSMUST00000175889.1
ENSMUST00000168998.2
 Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chrX_+_9199865 1.607 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr4_-_88033328 1.601 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr16_-_67620805 1.598 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr13_+_16011851 1.501 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr3_-_73056943 1.450 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr6_+_4903350 1.419 ENSMUST00000175962.1
 Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr14_-_55116935 1.364 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr10_-_42276688 1.227 ENSMUST00000175881.1
ENSMUST00000056974.3
 Foxo3

forkhead box O3

chr12_+_102948843 1.136 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr12_+_95692212 1.129 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr12_+_119945957 1.105 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chr11_-_77894096 1.074 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr17_+_74528467 1.056 ENSMUST00000182944.1
ENSMUST00000182597.1
ENSMUST00000182133.1
ENSMUST00000183224.1
 Birc6



baculoviral IAP repeat-containing 6



chr3_+_117575268 1.053 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr12_+_37880700 1.048 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0007631 feeding behavior(GO:0007631)
0.1 3.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.0 3.1 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 2.0 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.6 1.8 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.1 1.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 1.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 1.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 1.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 1.4 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 1.2 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.4 1.1 GO:0006553 lysine metabolic process(GO:0006553)
0.1 1.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.0 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.1 0.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.9 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 3.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 2.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.0 GO:0000922 spindle pole(GO:0000922)
0.6 1.8 GO:1990812 growth cone filopodium(GO:1990812)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.5 1.5 GO:0043512 inhibin A complex(GO:0043512)
0.3 1.4 GO:0030314 junctional membrane complex(GO:0030314)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.1 0.6 GO:0001940 male pronucleus(GO:0001940)
0.0 0.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.5 GO:0033010 paranodal junction(GO:0033010)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 1.8 GO:0033592 RNA strand annealing activity(GO:0033592)
0.3 1.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.5 GO:0045499 chemorepellent activity(GO:0045499)
0.3 1.4 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 1.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.2 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 1.2 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.3 1.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.6 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.5 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 1.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.2 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes