Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.727

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.647.7e-06Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.333.3e-02Click!
Irf2mm10_v2_chr8_+_46739745_467397910.324.1e-02Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.261.0e-01Click!
Irf7mm10_v2_chr7_-_141266415_141266481-0.076.7e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 64.842 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3034599 61.648 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3027439 61.081 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3023547 59.562 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3017408 56.646 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 55.853 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 54.829 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3004457 54.212 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3000922 52.967 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3037111 52.888 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr14_-_19418930 52.103 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3036877 50.404 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 47.906 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3018753 46.124 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3025417 45.465 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_+_98662227 26.293 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr19_+_36409719 20.482 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr2_-_105399286 20.414 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr2_-_51972990 17.808 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr11_+_119393060 16.146 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 287 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 169.4 GO:0008150 biological_process(GO:0008150)
4.6 45.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
7.4 22.3 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
1.5 16.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
3.6 14.4 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.1 12.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
1.5 11.8 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 11.0 GO:0010390 histone monoubiquitination(GO:0010390)
2.1 10.5 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
1.5 10.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.3 10.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
2.3 9.2 GO:0009597 detection of virus(GO:0009597)
0.6 9.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
1.5 8.7 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
1.1 8.6 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.8 8.5 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
1.5 7.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.8 7.1 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.2 7.1 GO:0006379 mRNA cleavage(GO:0006379)
1.7 7.0 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 461.0 GO:0005575 cellular_component(GO:0005575)
2.3 27.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 20.4 GO:0031519 PcG protein complex(GO:0031519)
0.9 14.7 GO:0005614 interstitial matrix(GO:0005614)
0.9 13.0 GO:0044754 secondary lysosome(GO:0005767) autolysosome(GO:0044754)
1.3 11.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 11.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 9.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 9.1 GO:0005923 bicellular tight junction(GO:0005923)
2.4 7.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 6.8 GO:0016235 aggresome(GO:0016235)
0.4 6.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 5.8 GO:0036126 sperm flagellum(GO:0036126)
1.4 5.4 GO:0097454 Schwann cell microvillus(GO:0097454)
1.8 5.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 5.2 GO:0005604 basement membrane(GO:0005604)
0.3 4.8 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 4.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.7 4.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.8 4.2 GO:1990462 omegasome(GO:1990462)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 303.1 GO:0003674 molecular_function(GO:0003674)
0.1 36.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.1 14.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 12.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.6 12.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 12.0 GO:0003924 GTPase activity(GO:0003924)
0.6 11.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.7 11.4 GO:0017166 vinculin binding(GO:0017166)
2.6 10.5 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 10.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 10.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.7 8.8 GO:0031386 protein tag(GO:0031386)
0.3 8.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 8.1 GO:0030332 cyclin binding(GO:0030332)
2.4 7.3 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
1.7 6.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 6.7 GO:0046332 SMAD binding(GO:0046332)
0.2 6.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
2.1 6.2 GO:0070052 collagen V binding(GO:0070052)
0.1 6.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 27.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 25.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 22.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 14.9 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.3 12.8 PID_BARD1_PATHWAY BARD1 signaling events
0.1 8.4 PID_PLK1_PATHWAY PLK1 signaling events
0.2 6.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 6.4 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 4.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 4.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.4 3.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 2.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.7 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.3 2.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.6 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 17.0 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.0 12.9 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
4.1 12.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 11.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.7 9.2 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.3 9.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 9.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 7.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 7.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 6.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 5.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.2 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 4.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 4.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 4.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 3.8 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.3 3.4 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 3.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase