Motif ID: Irf4

Z-value: 0.579


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_163313661 3.020 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr11_-_77894096 2.865 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr6_-_87335758 2.044 ENSMUST00000042025.9
 Antxr1
anthrax toxin receptor 1
chr3_+_90537306 1.955 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr3_+_90537242 1.887 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr1_+_16688405 1.840 ENSMUST00000026881.4
 Ly96
lymphocyte antigen 96
chrX_-_134161928 1.791 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr17_-_6782775 1.713 ENSMUST00000064234.6
 Ezr
ezrin
chr6_-_39118211 1.627 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr1_-_14310198 1.555 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr14_+_60732906 1.408 ENSMUST00000162945.1
 Spata13
spermatogenesis associated 13
chr8_+_84723003 1.390 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr1_-_97977233 1.343 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr2_+_128126030 1.282 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
 Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr11_+_119393060 1.249 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr9_-_116175318 1.246 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr9_+_85842852 1.192 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr16_-_43664145 1.185 ENSMUST00000096065.4
 Tigit
T cell immunoreceptor with Ig and ITIM domains
chr8_-_84773381 1.169 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr16_+_43235856 1.085 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0051592 response to calcium ion(GO:0051592)
0.2 3.0 GO:0048664 neuron fate determination(GO:0048664)
1.0 2.9 GO:0006553 lysine metabolic process(GO:0006553)
0.7 2.0 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.4 1.8 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.6 1.7 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.4 1.6 GO:0006710 androgen catabolic process(GO:0006710)
0.3 1.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.5 1.4 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 1.4 GO:0046847 filopodium assembly(GO:0046847)
0.3 1.3 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 1.3 GO:0009404 toxin metabolic process(GO:0009404)
0.4 1.2 GO:0003274 endocardial cushion fusion(GO:0003274)
0.1 1.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.1 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.1 0.9 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 0.9 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 2.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.3 1.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.6 1.7 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.4 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.1 0.4 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 0.4 GO:0097422 tubular endosome(GO:0097422)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0071837 HMG box domain binding(GO:0071837)
0.7 2.9 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 2.7 GO:0005518 collagen binding(GO:0005518)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.6 1.8 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 1.7 GO:0044548 S100 protein binding(GO:0044548)
0.2 1.6 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 1.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 1.3 GO:0070840 dynein complex binding(GO:0070840)
0.3 1.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 0.8 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.1 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.2 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 2.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 1.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 1.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 0.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction