Motif ID: Irx5

Z-value: 0.567


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.352.4e-02Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 68 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 4.937 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr12_+_55598917 3.210 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr2_-_79908428 2.776 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr7_-_114927726 2.135 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr2_-_79908389 2.080 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr3_+_124321031 1.401 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr9_-_78378725 1.338 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr6_+_50110837 1.337 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr12_+_38783503 1.313 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr2_-_85035487 1.047 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr5_-_88675190 0.910 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr1_+_165301863 0.895 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr14_-_19977040 0.867 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr11_-_68927049 0.861 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr3_+_95124476 0.855 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr12_-_108893197 0.854 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr14_-_19977151 0.833 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr10_+_3872667 0.827 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr1_-_78968079 0.792 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr10_-_99759658 0.778 ENSMUST00000056085.4
 Csl
citrate synthase like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 4.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.3 GO:0007566 embryo implantation(GO:0007566)
0.0 1.1 GO:0007338 single fertilization(GO:0007338)
0.3 1.0 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.3 0.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.9 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 0.7 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.7 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 0.7 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.6 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.2 0.5 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.1 0.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 0.4 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.9 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.5 GO:0070876 SOSS complex(GO:0070876)
0.1 0.5 GO:0012505 endomembrane system(GO:0012505)
0.0 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 0.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0097454 Schwann cell microvillus(GO:0097454)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 2.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.3 0.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.2 0.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.7 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.7 GO:0045545 syndecan binding(GO:0045545)
0.2 0.6 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.5 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 0.4 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.4 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres