Motif ID: Irx6_Irx2_Irx3

Z-value: 0.825

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72628831_72628971-0.163.1e-01Click!
Irx3mm10_v2_chr8_-_91801948_918020670.124.7e-01Click!
Irx6mm10_v2_chr8_+_92674826_926748260.047.8e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 7.844 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr17_+_17316078 2.782 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr9_-_124493793 2.570 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr8_+_84872105 2.496 ENSMUST00000136026.1
ENSMUST00000170296.1
 Syce2

synaptonemal complex central element protein 2

chr12_-_74316394 2.476 ENSMUST00000110441.1
 Gm11042
predicted gene 11042
chr10_+_61171954 2.289 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr18_+_36664060 1.945 ENSMUST00000036765.7
 Eif4ebp3
eukaryotic translation initiation factor 4E binding protein 3
chr18_+_35770318 1.853 ENSMUST00000165299.1
 Gm16490
predicted gene 16490
chr13_+_49504774 1.772 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr7_+_140763739 1.675 ENSMUST00000026552.7
 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr10_-_29699379 1.658 ENSMUST00000092620.4
 Gm10275
predicted pseudogene 10275
chr10_-_39122277 1.595 ENSMUST00000136546.1
 Fam229b
family with sequence similarity 229, member B
chr12_+_69963452 1.569 ENSMUST00000110560.1
 Gm3086
predicted gene 3086
chr6_-_48708206 1.545 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr2_-_98667264 1.502 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr13_+_23544052 1.408 ENSMUST00000075558.2
 Hist1h3f
histone cluster 1, H3f
chr2_-_67433181 1.362 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr3_+_106034661 1.313 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr17_-_25785533 1.292 ENSMUST00000140738.1
ENSMUST00000145053.1
ENSMUST00000138759.1
ENSMUST00000133071.1
ENSMUST00000077938.3
 Haghl




hydroxyacylglutathione hydrolase-like




chr14_-_31001311 1.286 ENSMUST00000161219.1
ENSMUST00000182501.1
 Spcs1

signal peptidase complex subunit 1 homolog (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 7.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 2.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.2 2.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 2.4 GO:0048515 spermatid differentiation(GO:0048515)
0.0 2.1 GO:0006334 nucleosome assembly(GO:0006334)
0.1 2.0 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.1 1.9 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 1.3 GO:0021591 ventricular system development(GO:0021591)
0.0 1.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 1.0 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.2 1.0 GO:0032382 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.0 1.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.3 0.9 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.2 0.9 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.9 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.9 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.0 0.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 6.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.8 2.5 GO:0000801 central element(GO:0000801)
0.1 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.8 GO:0000786 nucleosome(GO:0000786)
0.0 1.7 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.3 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.2 GO:0005687 U4 snRNP(GO:0005687)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.9 GO:0046930 pore complex(GO:0046930)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.2 0.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 0.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 3.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 2.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.7 2.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.2 1.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.6 1.8 GO:0070052 collagen V binding(GO:0070052)
0.0 1.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.3 GO:0043022 ribosome binding(GO:0043022)
0.1 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.0 GO:0050632 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.1 0.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.9 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.9 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.3 0.8 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.2 0.8 GO:0031720 haptoglobin binding(GO:0031720)
0.2 0.8 GO:0047134 protein-disulfide reductase activity(GO:0047134)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.3 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.1 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 2.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.7 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.0 REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM Genes involved in Bile acid and bile salt metabolism
0.0 1.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.9 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.8 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.7 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.1 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade