Motif ID: Isl1

Z-value: 0.428


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_1163096990.202.1e-01Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 4.465 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr14_-_118052235 2.255 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr7_+_45017953 2.170 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr7_-_25250720 1.840 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr15_-_50889691 1.718 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr3_-_49757257 1.678 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr1_-_56978534 1.524 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr9_+_35423582 1.232 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr4_-_14621805 1.232 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr10_-_13388753 1.184 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr15_+_62037986 1.167 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr14_+_124005355 1.100 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr5_-_37824580 1.030 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr4_-_137766474 0.952 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr19_+_55741810 0.931 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr8_+_84723003 0.817 ENSMUST00000098571.4
G430095P16Rik
RIKEN cDNA G430095P16 gene
chr2_-_72986716 0.787 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr3_+_89520152 0.775 ENSMUST00000000811.7
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr9_+_37367354 0.774 ENSMUST00000051839.7
Hepacam
hepatocyte cell adhesion molecule
chr4_-_82850721 0.732 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.5 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 2.7 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.4 2.5 GO:0019532 oxalate transport(GO:0019532)
0.3 2.5 GO:0048625 myoblast fate commitment(GO:0048625)
0.4 2.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 2.2 GO:0060325 face morphogenesis(GO:0060325)
0.4 1.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 1.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 1.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 1.0 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 0.7 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 0.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.7 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 0.6 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.2 0.6 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0005667 transcription factor complex(GO:0005667)
0.3 2.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 2.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.2 GO:0030175 filopodium(GO:0030175)
0.1 1.0 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 2.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 2.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 2.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.0 1.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 1.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 0.7 GO:0019808 polyamine binding(GO:0019808)
0.1 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.4 GO:0019002 GMP binding(GO:0019002)
0.1 0.4 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.3 GO:0004829 threonine-tRNA ligase activity(GO:0004829)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 PID_CDC42_PATHWAY CDC42 signaling events
0.0 2.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 0.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE