Motif ID: Isl2
Z-value: 0.781
Transcription factors associated with Isl2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Isl2 | ENSMUSG00000032318.6 | Isl2 |
Top targets:
Showing 1 to 20 of 175 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 64 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | GO:0007530 | sex determination(GO:0007530) |
| 1.1 | 3.2 | GO:0015938 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356) |
| 0.2 | 3.2 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 1.0 | 3.0 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.4 | 2.6 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.8 | 2.5 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.2 | 2.3 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.1 | 2.3 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 2.2 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 2.1 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.7 | 2.0 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.0 | 1.9 | GO:0021591 | ventricular system development(GO:0021591) |
| 0.0 | 1.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.3 | 1.8 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.2 | 1.7 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.5 | 1.6 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.4 | 1.6 | GO:0072592 | regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
| 0.2 | 1.6 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.0 | 1.5 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 1.5 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 2.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 2.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 2.3 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.5 | 1.8 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.0 | 1.8 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 1.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 1.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 1.5 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.3 | 1.2 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.1 | 1.1 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.0 | 1.1 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 1.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.0 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 1.0 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 1.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 0.9 | GO:0060187 | cell pole(GO:0060187) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 46 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 1.1 | 3.2 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.8 | 3.0 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 2.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.4 | 2.5 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 2.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 2.3 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
| 0.0 | 2.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.4 | 2.1 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.6 | 1.8 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.4 | 1.8 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 1.7 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.5 | 1.6 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.1 | 1.6 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 1.5 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.3 | 1.3 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.1 | 1.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 1.3 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
| 0.2 | 1.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 1.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
Gene overrepresentation in C2:CP category:
Showing 1 to 13 of 13 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 2.7 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.8 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 1.6 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.3 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.7 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 28 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 2.6 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.2 | 2.5 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 2.1 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.1 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.8 | REACTOME_SIGNALING_BY_FGFR | Genes involved in Signaling by FGFR |
| 0.0 | 1.5 | REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 1.4 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 1.3 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 1.3 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.0 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.0 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.7 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 0.7 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.7 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.7 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
