Motif ID: Jun

Z-value: 0.463


Transcription factors associated with Jun:

Gene SymbolEntrez IDGene Name
Jun ENSMUSG00000052684.3 Jun

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junmm10_v2_chr4_-_95052170_95052181-0.279.1e-02Click!


Activity profile for motif Jun.

activity profile for motif Jun


Sorted Z-values histogram for motif Jun

Sorted Z-values for motif Jun



Network of associatons between targets according to the STRING database.



First level regulatory network of Jun

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_88503187 1.605 ENSMUST00000120377.1
 Lmna
lamin A
chr6_+_7555053 1.424 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr3_+_109573907 1.406 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr7_+_139834148 1.378 ENSMUST00000026548.7
 Gpr123
G protein-coupled receptor 123
chr3_-_88503331 1.252 ENSMUST00000029699.6
 Lmna
lamin A
chr10_-_5922385 1.019 ENSMUST00000131996.1
ENSMUST00000064225.7
 Rgs17

regulator of G-protein signaling 17

chr17_+_43953191 1.004 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr10_+_128933782 0.931 ENSMUST00000099112.2
 Itga7
integrin alpha 7
chrX_+_52791179 0.881 ENSMUST00000101588.1
 Ccdc160
coiled-coil domain containing 160
chr2_-_77703252 0.825 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr7_-_142372210 0.784 ENSMUST00000084412.5
 Ifitm10
interferon induced transmembrane protein 10
chr17_+_43952999 0.778 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr10_-_5922341 0.756 ENSMUST00000117676.1
ENSMUST00000019909.7
 Rgs17

regulator of G-protein signaling 17

chr1_-_180193475 0.744 ENSMUST00000160482.1
ENSMUST00000170472.1
 Adck3

aarF domain containing kinase 3

chr13_+_75839868 0.725 ENSMUST00000022082.7
 Glrx
glutaredoxin
chr16_-_26989974 0.690 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr7_-_142899985 0.674 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr10_-_76725978 0.656 ENSMUST00000001147.4
 Col6a1
collagen, type VI, alpha 1
chr2_+_165655237 0.645 ENSMUST00000063433.7
 Eya2
eyes absent 2 homolog (Drosophila)
chr10_+_26078255 0.612 ENSMUST00000041011.3
 Gm9767
predicted gene 9767

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 1.8 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.5 1.4 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 1.4 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.2 1.0 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 1.0 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 0.9 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.9 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 0.7 GO:0042414 epinephrine metabolic process(GO:0042414)
0.2 0.7 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 0.7 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.7 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.6 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 0.6 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.6 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 GO:0005638 lamin filament(GO:0005638)
0.2 1.2 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.1 1.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.0 GO:0002080 acrosomal membrane(GO:0002080)
0.3 0.9 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.2 0.7 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.7 GO:0044754 autolysosome(GO:0044754)
0.1 0.6 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.6 GO:0097227 sperm annulus(GO:0097227)
0.2 0.5 GO:0098842 postsynaptic early endosome(GO:0098842)
0.1 0.4 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.4 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 0.3 GO:0097513 myosin II filament(GO:0097513)
0.1 0.2 GO:1990047 spindle matrix(GO:1990047)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.8 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.0 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.2 0.9 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 0.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.9 GO:0043236 laminin binding(GO:0043236)
0.2 0.7 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153)
0.1 0.7 GO:0035240 dopamine binding(GO:0035240)
0.1 0.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.6 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.5 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021)
0.0 0.5 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.8 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.5 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.1 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling