Motif ID: Klf1

Z-value: 2.128


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.391.1e-02Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_46179929 12.020 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr15_+_83791939 11.369 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr7_+_44310213 11.065 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr6_+_5725639 9.758 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr10_-_81025521 9.454 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr5_-_139325616 9.336 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr6_+_103510874 8.804 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr7_-_103813913 8.513 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr5_+_117781017 8.316 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr11_+_104231465 8.110 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr11_+_104231515 8.020 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr2_-_162661075 7.453 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr2_+_92599671 7.335 ENSMUST00000065797.6
 Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr12_-_4841583 7.261 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr14_+_80000292 7.246 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr10_+_127078886 7.221 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_+_104231390 7.099 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr10_+_106470281 6.413 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr8_+_84723003 6.388 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr6_+_54681687 6.359 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 578 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 28.5 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.3 23.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.5 15.1 GO:0046959 habituation(GO:0046959)
0.8 13.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.3 12.9 GO:0010459 negative regulation of heart rate(GO:0010459)
2.2 11.2 GO:1905075 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.6 11.0 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 11.0 GO:0030032 lamellipodium assembly(GO:0030032)
2.5 10.0 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
3.2 9.6 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
3.1 9.3 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
1.9 9.3 GO:0060178 regulation of exocyst localization(GO:0060178)
0.4 9.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.4 8.7 GO:0003350 pulmonary myocardium development(GO:0003350)
0.8 8.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 8.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.0 8.3 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.3 8.2 GO:0016578 histone deubiquitination(GO:0016578)
0.1 8.1 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.5 8.0 GO:0033623 regulation of integrin activation(GO:0033623)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 224 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 37.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 31.3 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.5 28.2 GO:0034704 calcium channel complex(GO:0034704)
2.5 24.8 GO:0045298 tubulin complex(GO:0045298)
0.1 18.3 GO:0014069 postsynaptic density(GO:0014069)
0.5 16.5 GO:0030673 axolemma(GO:0030673)
3.4 13.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.8 13.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 12.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
3.0 12.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.7 11.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 10.4 GO:0008021 synaptic vesicle(GO:0008021)
3.3 9.8 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.2 9.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.7 9.5 GO:0008385 IkappaB kinase complex(GO:0008385)
1.9 9.3 GO:1990761 growth cone lamellipodium(GO:1990761)
0.8 9.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 9.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 9.0 GO:0016235 aggresome(GO:0016235)
0.3 8.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 350 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.7 GO:0005096 GTPase activator activity(GO:0005096)
4.3 29.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.4 24.2 GO:0005267 potassium channel activity(GO:0005267)
0.1 21.9 GO:0003924 GTPase activity(GO:0003924)
3.8 15.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
3.4 13.4 GO:0031720 haptoglobin binding(GO:0031720)
1.0 13.2 GO:0038191 neuropilin binding(GO:0038191)
0.5 12.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 11.9 GO:0030507 spectrin binding(GO:0030507)
0.2 11.8 GO:0030276 clathrin binding(GO:0030276)
0.8 11.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 11.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.7 10.7 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.2 10.4 GO:0003777 microtubule motor activity(GO:0003777)
0.2 10.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 10.1 GO:0015485 cholesterol binding(GO:0015485)
0.8 10.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.5 9.8 GO:0050811 GABA receptor binding(GO:0050811)
0.5 9.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.5 9.1 GO:0070300 phosphatidic acid binding(GO:0070300)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 26.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 13.1 PID_ARF6_PATHWAY Arf6 signaling events
0.2 10.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 9.0 PID_LKB1_PATHWAY LKB1 signaling events
0.2 8.9 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 8.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 8.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 8.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 8.0 PID_EPO_PATHWAY EPO signaling pathway
0.2 7.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 7.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 5.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 5.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 5.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 5.2 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.3 4.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 4.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 3.8 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 3.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.3 PID_SHP2_PATHWAY SHP2 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 31.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 26.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 20.9 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 18.5 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 14.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 13.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.6 12.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 12.0 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 11.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 10.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.5 9.2 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.1 8.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 8.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.6 8.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 8.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 8.1 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.4 7.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 7.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 6.9 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.2 6.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis