Motif ID: Klf15

Z-value: 1.297


Transcription factors associated with Klf15:

Gene SymbolEntrez IDGene Name
Klf15 ENSMUSG00000030087.5 Klf15

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf15mm10_v2_chr6_+_90465287_904653040.343.2e-02Click!


Activity profile for motif Klf15.

activity profile for motif Klf15


Sorted Z-values histogram for motif Klf15

Sorted Z-values for motif Klf15



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 10.479 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr18_-_89769479 9.034 ENSMUST00000097495.3
 Dok6
docking protein 6
chr11_+_50602072 6.711 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr1_-_56972437 5.993 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr3_+_118433797 5.966 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr11_+_69765970 5.207 ENSMUST00000108642.1
ENSMUST00000156932.1
 Zbtb4

zinc finger and BTB domain containing 4

chr5_+_137288273 5.128 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr7_+_46396439 4.921 ENSMUST00000025202.6
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr1_-_161034794 4.683 ENSMUST00000177003.1
ENSMUST00000162226.2
ENSMUST00000159250.2
 Zbtb37


zinc finger and BTB domain containing 37


chr17_+_46297917 4.674 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr10_-_127666598 4.662 ENSMUST00000099157.3
 Nab2
Ngfi-A binding protein 2
chr11_-_54068932 4.564 ENSMUST00000093109.4
ENSMUST00000018755.3
 Pdlim4

PDZ and LIM domain 4

chr11_+_69765899 4.455 ENSMUST00000108640.1
ENSMUST00000108639.1
 Zbtb4

zinc finger and BTB domain containing 4

chr10_-_127666673 4.072 ENSMUST00000026469.2
 Nab2
Ngfi-A binding protein 2
chr19_+_5740885 3.876 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chrX_-_136868537 3.835 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr9_+_21927471 3.815 ENSMUST00000170304.1
ENSMUST00000006403.6
 Ccdc159

coiled-coil domain containing 159

chr15_+_57694651 3.686 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr18_-_66291770 3.615 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr6_-_53068562 3.592 ENSMUST00000074541.5
 Jazf1
JAZF zinc finger 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.2 8.7 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.4 6.7 GO:0030574 collagen catabolic process(GO:0030574)
1.0 6.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 5.9 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 5.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.9 5.1 GO:0019695 choline metabolic process(GO:0019695)
0.4 4.9 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.2 4.6 GO:0006491 N-glycan processing(GO:0006491)
0.5 4.4 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
1.3 3.9 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 3.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 3.8 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 3.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.9 3.6 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.4 3.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.3 3.6 GO:0035635 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.6 3.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.6 3.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.4 3.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 7.0 GO:0001650 fibrillar center(GO:0001650)
2.3 6.8 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 6.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 6.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 5.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 5.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.3 GO:0030175 filopodium(GO:0030175)
0.3 5.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 4.9 GO:0030673 axolemma(GO:0030673)
0.9 4.6 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 4.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 4.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 3.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 3.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 3.6 GO:0032584 growth cone membrane(GO:0032584)
0.6 3.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
1.1 3.2 GO:0098855 HCN channel complex(GO:0098855)
0.2 3.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 9.0 GO:0005158 insulin receptor binding(GO:0005158)
0.2 8.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 6.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 5.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.3 5.1 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.3 4.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.5 4.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 4.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 4.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.8 GO:0019003 GDP binding(GO:0019003)
0.0 3.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 3.6 GO:0005518 collagen binding(GO:0005518)
0.0 3.6 GO:0000287 magnesium ion binding(GO:0000287)
0.1 3.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 3.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 3.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 3.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.0 GO:0019213 deacetylase activity(GO:0019213)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 6.2 PID_CDC42_PATHWAY CDC42 signaling events
0.1 5.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 4.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 4.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 4.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 3.0 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 3.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 2.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 7.4 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events
0.2 5.1 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 4.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.2 3.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 3.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 3.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 2.9 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 2.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.9 2.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 2.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.3 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 1.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.4 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation