Motif ID: Klf16_Sp8

Z-value: 1.271

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp8mm10_v2_chr12_+_118846329_1188463290.594.3e-05Click!
Klf16mm10_v2_chr10_-_80577285_80577327-0.278.3e-02Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_32166879 9.724 ENSMUST00000087723.3
 Notch3
notch 3
chr12_+_108334341 9.200 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr11_+_78322965 8.933 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr7_-_38107490 8.455 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr18_+_49979514 7.396 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr10_+_108332173 7.344 ENSMUST00000095313.3
 Pawr
PRKC, apoptosis, WT1, regulator
chr12_+_103314944 7.313 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr5_+_140607334 7.252 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_-_119578981 7.037 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr12_+_17690793 7.027 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr18_+_49979427 6.963 ENSMUST00000148989.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr4_-_117133953 6.846 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr5_+_33721724 6.726 ENSMUST00000067150.7
ENSMUST00000169212.2
ENSMUST00000114411.2
ENSMUST00000164207.3
 Fgfr3



fibroblast growth factor receptor 3



chr4_-_41695442 6.680 ENSMUST00000102961.3
ENSMUST00000064443.6
 Cntfr

ciliary neurotrophic factor receptor

chr10_-_80329426 6.635 ENSMUST00000020340.8
 Pcsk4
proprotein convertase subtilisin/kexin type 4
chr7_-_127026479 6.602 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr17_-_25797032 6.539 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr17_-_70851189 6.498 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr2_+_164562579 6.452 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr4_-_55532453 6.313 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,090 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 23.3 GO:0030903 notochord development(GO:0030903)
3.3 23.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.7 20.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.8 18.6 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.5 15.9 GO:0006270 DNA replication initiation(GO:0006270)
0.4 15.4 GO:0051310 metaphase plate congression(GO:0051310)
0.8 15.2 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.7 15.0 GO:0044458 motile cilium assembly(GO:0044458)
0.3 14.1 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.7 13.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
1.3 13.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
2.6 12.9 GO:0007386 compartment pattern specification(GO:0007386)
1.6 12.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.9 11.6 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.0 11.4 GO:0008380 RNA splicing(GO:0008380)
2.8 11.3 GO:0003360 brainstem development(GO:0003360)
1.1 11.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 10.6 GO:0051764 actin crosslink formation(GO:0051764)
0.4 10.4 GO:0034508 centromere complex assembly(GO:0034508)
3.4 10.3 GO:1904274 tricellular tight junction assembly(GO:1904274)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 362 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 54.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 33.0 GO:0016607 nuclear speck(GO:0016607)
0.5 29.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 28.4 GO:0005844 polysome(GO:0005844)
0.1 17.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 17.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 16.9 GO:0005615 extracellular space(GO:0005615)
0.3 16.2 GO:0005876 spindle microtubule(GO:0005876)
0.3 16.2 GO:0017053 transcriptional repressor complex(GO:0017053)
1.6 14.6 GO:0000796 condensin complex(GO:0000796)
0.1 14.2 GO:0000785 chromatin(GO:0000785)
0.5 12.9 GO:0001741 XY body(GO:0001741)
0.2 12.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.7 11.7 GO:0042627 chylomicron(GO:0042627)
3.8 11.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
2.3 11.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 10.3 GO:0015934 large ribosomal subunit(GO:0015934)
0.3 10.1 GO:0000791 euchromatin(GO:0000791)
0.2 9.9 GO:0005581 collagen trimer(GO:0005581)
3.2 9.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 584 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 31.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 27.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 27.4 GO:0042393 histone binding(GO:0042393)
0.3 25.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.6 22.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 21.7 GO:0003682 chromatin binding(GO:0003682)
0.7 20.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 16.0 GO:0001047 core promoter binding(GO:0001047)
0.2 15.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.1 15.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.3 15.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.6 14.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.6 13.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 13.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 12.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
2.5 12.5 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.9 12.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 11.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 11.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
1.9 11.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 37.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 32.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.6 31.0 PID_PLK1_PATHWAY PLK1 signaling events
0.4 31.0 PID_E2F_PATHWAY E2F transcription factor network
0.3 30.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
1.8 24.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 19.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 17.1 NABA_COLLAGENS Genes encoding collagen proteins
0.1 14.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 13.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 12.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 12.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 12.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 10.9 PID_FGF_PATHWAY FGF signaling pathway
0.2 10.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 10.3 PID_BMP_PATHWAY BMP receptor signaling
0.2 9.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 9.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 8.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 8.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 36.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 28.8 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.3 28.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.8 24.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6 24.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 23.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
1.2 23.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 23.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 21.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
1.2 16.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.5 15.9 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.6 15.5 REACTOME_KINESINS Genes involved in Kinesins
0.6 15.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
1.2 11.0 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.7 10.5 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 10.1 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.6 9.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.5 9.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 9.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.7 9.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport