Motif ID: Klf6_Patz1

Z-value: 1.319

Transcription factors associated with Klf6_Patz1:

Gene SymbolEntrez IDGene Name
Klf6 ENSMUSG00000000078.6 Klf6
Patz1 ENSMUSG00000020453.11 Patz1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Patz1mm10_v2_chr11_+_3289880_32899930.278.3e-02Click!
Klf6mm10_v2_chr13_+_5861489_58615010.076.6e-01Click!


Activity profile for motif Klf6_Patz1.

activity profile for motif Klf6_Patz1


Sorted Z-values histogram for motif Klf6_Patz1

Sorted Z-values for motif Klf6_Patz1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf6_Patz1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102296618 8.881 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chrX_+_13071470 5.062 ENSMUST00000169594.2
 Usp9x
ubiquitin specific peptidase 9, X chromosome
chr16_+_44173271 4.977 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr7_+_44310213 4.873 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr16_+_44173239 4.535 ENSMUST00000119746.1
 Gm608
predicted gene 608
chr6_-_119848059 4.449 ENSMUST00000184864.1
 Erc1
ELKS/RAB6-interacting/CAST family member 1
chr7_+_28180272 4.307 ENSMUST00000173223.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr8_+_107293500 4.232 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr7_+_28180226 4.206 ENSMUST00000172467.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr1_-_155417394 4.151 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr14_-_20794009 4.081 ENSMUST00000100837.3
ENSMUST00000080440.6
ENSMUST00000071816.6
 Camk2g


calcium/calmodulin-dependent protein kinase II gamma


chr19_+_6418731 4.066 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
 Nrxn2


neurexin II


chr10_-_127620960 4.060 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr2_-_161109017 4.037 ENSMUST00000039782.7
ENSMUST00000134178.1
 Chd6

chromodomain helicase DNA binding protein 6

chr2_-_24763047 3.984 ENSMUST00000100348.3
ENSMUST00000041342.5
ENSMUST00000114447.1
ENSMUST00000102939.2
ENSMUST00000070864.7
 Cacna1b




calcium channel, voltage-dependent, N type, alpha 1B subunit




chr17_-_45686120 3.925 ENSMUST00000143907.1
ENSMUST00000127065.1
 Tmem63b

transmembrane protein 63b

chr12_-_27342696 3.775 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11
chr5_-_25498702 3.728 ENSMUST00000173073.1
ENSMUST00000045291.7
 Kmt2c

lysine (K)-specific methyltransferase 2C

chr7_+_25268387 3.575 ENSMUST00000169392.1
 Cic
capicua homolog (Drosophila)
chr1_-_161034794 3.556 ENSMUST00000177003.1
ENSMUST00000162226.2
ENSMUST00000159250.2
 Zbtb37


zinc finger and BTB domain containing 37



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 742 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 22.8 GO:0071625 vocalization behavior(GO:0071625)
0.6 10.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.3 10.3 GO:0007520 myoblast fusion(GO:0007520)
0.1 10.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
2.2 8.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.3 8.1 GO:0016578 histone deubiquitination(GO:0016578)
0.4 7.9 GO:1903859 regulation of dendrite extension(GO:1903859)
0.1 7.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 6.6 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.4 6.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.8 6.1 GO:0035608 protein deglutamylation(GO:0035608)
1.0 6.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
1.8 5.5 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.1 5.4 GO:0051684 maintenance of Golgi location(GO:0051684)
0.3 5.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.3 5.2 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
1.2 4.9 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.4 4.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.9 4.6 GO:0007256 activation of JNKK activity(GO:0007256)
0.7 4.5 GO:0061535 glutamate secretion, neurotransmission(GO:0061535)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 262 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 25.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 24.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 14.2 GO:0042734 presynaptic membrane(GO:0042734)
0.2 13.7 GO:0055037 recycling endosome(GO:0055037)
0.8 11.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 10.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 8.9 GO:0008021 synaptic vesicle(GO:0008021)
0.4 8.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 8.6 GO:0016605 PML body(GO:0016605)
0.0 8.4 GO:0005768 endosome(GO:0005768)
0.2 8.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 7.6 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.6 7.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.4 7.0 GO:0000124 SAGA complex(GO:0000124)
0.2 7.0 GO:0043194 axon initial segment(GO:0043194)
0.2 6.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 6.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.5 6.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.2 6.0 GO:0090544 BAF-type complex(GO:0090544)
0.2 5.7 GO:0035371 microtubule plus-end(GO:0035371)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 421 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 19.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 16.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 16.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 14.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 13.4 GO:0008017 microtubule binding(GO:0008017)
0.2 10.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 9.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 9.4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 9.2 GO:0017075 syntaxin-1 binding(GO:0017075)
3.0 8.9 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.5 8.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.2 7.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 7.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.7 6.9 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.9 6.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 6.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 6.8 GO:0005262 calcium channel activity(GO:0005262)
2.2 6.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 6.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.6 13.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 11.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 11.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 9.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 8.4 PID_LKB1_PATHWAY LKB1 signaling events
0.5 7.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 7.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 7.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 5.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 5.0 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 4.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.2 PID_ERBB4_PATHWAY ErbB4 signaling events
0.4 3.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 3.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 3.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 13.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 9.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.8 8.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.4 7.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 6.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 6.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 4.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.4 4.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 4.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 4.3 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 4.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 4.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 4.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 4.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 4.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 3.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.7 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.2 3.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.7 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling