Motif ID: Klf7

Z-value: 0.578


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121389_64121452-0.552.3e-04Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_897782 4.715 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr5_+_140607334 4.137 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr12_+_118846329 1.854 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr12_-_4592927 1.702 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr2_+_119047116 1.494 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr5_+_33658123 1.244 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr2_+_119047129 1.192 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr1_-_120121030 1.183 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr15_+_99074968 1.164 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr1_-_120120937 1.077 ENSMUST00000151708.1
 Dbi
diazepam binding inhibitor
chr7_+_58658181 0.994 ENSMUST00000168747.1
 Atp10a
ATPase, class V, type 10A
chr5_+_137778849 0.988 ENSMUST00000126126.1
ENSMUST00000031739.4
 Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr2_+_172550991 0.977 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr11_-_70654624 0.901 ENSMUST00000018437.2
 Pfn1
profilin 1
chr10_+_79682169 0.891 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr7_-_116198487 0.820 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr12_-_11436607 0.808 ENSMUST00000072299.5
 Vsnl1
visinin-like 1
chr13_+_21722057 0.782 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr8_+_70152754 0.694 ENSMUST00000072500.6
ENSMUST00000164040.1
ENSMUST00000110146.2
ENSMUST00000110143.1
ENSMUST00000110141.2
ENSMUST00000110140.1
 2310045N01Rik

Mef2b



RIKEN cDNA 2310045N01 gene

myocyte enhancer factor 2B



chr5_+_137761680 0.693 ENSMUST00000110983.2
ENSMUST00000031738.4
 Tsc22d4

TSC22 domain family, member 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.8 4.1 GO:0007386 compartment pattern specification(GO:0007386)
0.5 2.3 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 1.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 1.6 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.3 1.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.0 1.0 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.9 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.8 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.2 0.7 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.1 0.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.6 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.6 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 0.5 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 0.5 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.1 0.5 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.1 0.7 GO:0097255 R2TP complex(GO:0097255)
0.1 0.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.5 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.3 GO:0070938 contractile ring(GO:0070938)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.2 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.7 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
1.4 4.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.8 2.3 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 1.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.2 0.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.7 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.1 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 PID_CONE_PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 0.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors