Motif ID: Klf8

Z-value: 1.279


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.323.8e-02Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_72788952 12.688 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr17_-_70851189 11.940 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr18_-_74961252 10.190 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr13_-_60177357 9.646 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr2_-_36105271 9.606 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr9_-_8004585 9.410 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr14_-_103843685 8.485 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr7_+_4119525 8.076 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 8.027 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr4_+_46450892 6.953 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_-_127026479 6.671 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr18_-_78206408 6.511 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr1_+_172499948 6.152 ENSMUST00000111230.1
 Tagln2
transgelin 2
chr10_+_4710119 5.899 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr13_+_48261427 5.853 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr1_-_20820213 5.712 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr7_+_144838590 4.732 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr7_-_144939823 4.594 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr7_+_126847908 4.537 ENSMUST00000147257.1
ENSMUST00000139174.1
 Doc2a

double C2, alpha

chr7_-_30973464 4.047 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.9 14.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.2 12.7 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
2.5 10.2 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
1.6 9.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.0 9.6 GO:0042473 outer ear morphogenesis(GO:0042473)
1.6 9.4 GO:0060242 contact inhibition(GO:0060242)
1.4 8.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
2.8 8.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.2 7.3 GO:0009299 mRNA transcription(GO:0009299)
0.3 7.0 GO:0043486 histone exchange(GO:0043486)
1.0 6.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
2.2 6.5 GO:0071918 urea transmembrane transport(GO:0071918)
1.6 6.3 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
1.5 5.9 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 5.7 GO:0006270 DNA replication initiation(GO:0006270)
0.6 5.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.7 4.7 GO:0030916 otic vesicle formation(GO:0030916)
0.7 4.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 4.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.4 GO:0005667 transcription factor complex(GO:0005667)
5.4 16.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.3 10.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
3.1 9.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.6 7.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.2 7.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 6.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 6.0 GO:0031965 nuclear membrane(GO:0031965)
0.8 5.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.4 5.7 GO:0042555 MCM complex(GO:0042555)
0.0 5.1 GO:0031012 extracellular matrix(GO:0031012)
1.4 4.1 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.7 4.0 GO:0061689 tricellular tight junction(GO:0061689)
0.0 3.9 GO:0005769 early endosome(GO:0005769)
0.8 3.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.6 3.7 GO:0005859 muscle myosin complex(GO:0005859)
0.4 3.3 GO:0031415 NatA complex(GO:0031415)
0.1 3.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 2.9 GO:0000796 condensin complex(GO:0000796)
0.9 2.6 GO:0005588 collagen type V trimer(GO:0005588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 16.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.7 14.7 GO:0070410 co-SMAD binding(GO:0070410)
0.4 12.4 GO:0070064 proline-rich region binding(GO:0070064)
2.5 10.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 8.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
2.8 8.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 7.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 7.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.1 6.5 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 6.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.0 5.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 5.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.2 5.0 GO:0008142 oxysterol binding(GO:0008142)
0.1 5.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 4.9 GO:0004386 helicase activity(GO:0004386)
0.3 4.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 4.0 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 4.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 3.9 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 24.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 19.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 15.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 9.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 6.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 5.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 4.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 3.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 2.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 2.0 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.9 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 16.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 13.0 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.5 8.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 7.8 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 7.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 7.3 REACTOME_TRANSLATION Genes involved in Translation
0.2 6.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 6.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.3 5.6 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.4 4.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 4.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.3 3.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 3.6 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 3.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 2.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.5 REACTOME_KINESINS Genes involved in Kinesins
0.2 2.4 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.3 2.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes