Motif ID: Lef1

Z-value: 1.662


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.221.6e-01Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_73271925 16.767 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr3_-_57575760 15.271 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575907 13.883 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr2_+_70474923 13.750 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr12_-_119238794 13.150 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr19_-_59170978 12.306 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr8_-_46294592 11.319 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr2_+_71528657 11.094 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr5_+_75075464 10.472 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr15_-_8710734 9.068 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_26092149 8.635 ENSMUST00000114159.2
 Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr15_-_8710409 7.865 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_59482133 6.956 ENSMUST00000114246.2
ENSMUST00000037105.6
 Fzd7

frizzled homolog 7 (Drosophila)

chr19_+_55742242 6.238 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr7_-_115824699 6.028 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr12_+_103314944 5.752 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr17_-_70851189 5.727 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr4_-_58499398 5.552 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr11_+_108920800 5.090 ENSMUST00000140821.1
 Axin2
axin2
chr2_+_116067213 4.933 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 29.2 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
2.3 18.3 GO:0048625 myoblast fate commitment(GO:0048625)
4.2 16.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.6 14.4 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 13.2 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.8 12.2 GO:0001573 ganglioside metabolic process(GO:0001573)
0.8 12.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 11.9 GO:2000739 regulation of mesenchymal stem cell differentiation(GO:2000739)
3.9 11.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.7 11.2 GO:0097154 GABAergic neuron differentiation(GO:0097154)
3.7 11.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.4 10.8 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.9 10.5 GO:0048853 forebrain morphogenesis(GO:0048853)
0.1 8.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.7 8.6 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 7.6 GO:0060612 adipose tissue development(GO:0060612)
2.4 7.3 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.7 7.0 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.3 6.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.3 6.5 GO:0060242 contact inhibition(GO:0060242)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 72.4 GO:0005667 transcription factor complex(GO:0005667)
2.0 18.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 17.2 GO:0043197 dendritic spine(GO:0043197)
0.6 13.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 11.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.4 8.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 8.5 GO:0005614 interstitial matrix(GO:0005614)
0.2 5.8 GO:0055038 recycling endosome membrane(GO:0055038)
1.2 4.8 GO:0008623 CHRAC(GO:0008623)
0.0 4.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 4.1 GO:0072686 mitotic spindle(GO:0072686)
0.5 3.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.2 3.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 3.3 GO:0042555 MCM complex(GO:0042555)
0.8 3.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 3.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.6 2.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 2.8 GO:0016580 Sin3 complex(GO:0016580)
0.2 2.8 GO:0044294 dendritic growth cone(GO:0044294)
0.0 2.7 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 40.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 32.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 22.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 19.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
2.8 16.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 14.5 GO:0003682 chromatin binding(GO:0003682)
1.9 13.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.5 12.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.6 11.1 GO:0070411 I-SMAD binding(GO:0070411)
0.0 8.8 GO:0051015 actin filament binding(GO:0051015)
0.3 8.7 GO:0001968 fibronectin binding(GO:0001968)
0.2 8.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 8.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 7.4 GO:0042805 actinin binding(GO:0042805)
0.1 7.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.3 7.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 6.0 GO:0004697 protein kinase C activity(GO:0004697)
0.4 5.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 5.7 GO:0070410 co-SMAD binding(GO:0070410)
0.8 5.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 55.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.7 13.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 13.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 7.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 6.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 5.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 4.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 4.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 3.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.3 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 3.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 3.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 2.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.3 PID_SHP2_PATHWAY SHP2 signaling
0.0 2.2 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 32.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 19.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 15.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 8.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.1 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 5.5 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 5.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5 5.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 4.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 4.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 3.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.5 3.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.1 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 3.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 2.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 2.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.5 2.3 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR