Motif ID: Lhx3

Z-value: 0.523


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 3.573 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr7_-_45103747 3.568 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr18_+_57468478 2.879 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr4_+_118961578 2.543 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr14_+_80000292 2.510 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr13_+_49608030 2.204 ENSMUST00000021822.5
Ogn
osteoglycin
chr3_+_151437887 2.167 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr1_+_177444653 1.701 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr13_-_101692624 1.670 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr8_-_21906412 1.477 ENSMUST00000051965.4
Defb11
defensin beta 11
chr1_-_158356258 1.460 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_+_36506814 1.430 ENSMUST00000167191.1
ENSMUST00000058738.4
Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr2_-_33086366 1.249 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_160619971 1.241 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr2_-_33087169 1.239 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_62766153 1.198 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_125136692 1.179 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr5_-_70842617 1.094 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr11_+_109543694 1.029 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr14_-_108914237 0.980 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 2.5 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.2 1.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 1.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.5 GO:0042742 defense response to bacterium(GO:0042742)
0.2 1.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 1.3 GO:0021549 cerebellum development(GO:0021549)
0.0 1.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 1.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 0.9 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 0.9 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.7 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.5 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.5 GO:0042581 specific granule(GO:0042581)
0.1 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.0 GO:0042629 mast cell granule(GO:0042629)
0.1 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0070469 respiratory chain(GO:0070469)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.1 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.7 3.6 GO:0019770 IgG receptor activity(GO:0019770)
0.8 2.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 2.2 GO:0008083 growth factor activity(GO:0008083)
0.4 1.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 1.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 1.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.1 0.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 2.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation